In Vivo Interaction Study
No Effect (based on bioequivalence limits) was detected.
- CYP2E1 4173608
|Sample||Compound measured||Value||Measurement||Study sequence||Additional information||N replicates|
Probe cocktail study
CYP2D6 ultra-rapid metabolizer
(6 females) (age, mean ± SD = 24 ± 3.0 years; weight, 69.3 ± 14.2 kg)
Did not use botanical dietary supplements or non-prescription/prescription medications aside from oral contraception in the female group, which they continued.
All females had a negative prenancy test at baseline
Drug or Natural Product Administration
twice in 28 day trial
three times daily
Wild Oats Markets, Inc. Boulder, CO.)
Pharmacodynamics (PD) & Adverse Events
Headache and Nausea