- Natural product: Goldenseal (Hydrastis canadensis)
- Associated study: In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4 phenotypes
In Vivo Interaction Study
CYP2E1 Experiment
No Effect (based on bioequivalence limits) was detected.
- CYP2E1 4173608
Results
Table 1
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
Probe cocktail study
Fixed-sequence
Multiple dosing
Females
Healthy volunteers
Males
Nonsmokers
CYP2D6 ultra-rapid metabolizer
12
(6 females) (age, mean ± SD = 24 ± 3.0 years; weight, 69.3 ± 14.2 kg)
Did not use botanical dietary supplements or non-prescription/prescription medications aside from oral contraception in the female group, which they continued.
All females had a negative prenancy test at baseline
2 hours
Drug or Natural Product Administration
Oral
not specified
250 mg
once
twice in 28 day trial
Oral
capsule
2700 mg
three times daily
28 days
Wild Oats Markets, Inc. Boulder, CO.)
not specified
Pharmacodynamics (PD) & Adverse Events
Headache and Nausea