- Natural product: Goldenseal (Hydrastis canadensis)
- Associated study: A clinical study of transporter-mediated goldenseal drug interactions
In Vivo Interaction Study
clinical goldenseal - rosuvastatin lactone experiment
No Effect (based on bioequivalence limits) was detected.
- OATP1B1 (SLCO1B1)
- OATP1B3 (SLCO1B3)
Results
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
Probe cocktail study
Fixed-sequence
Healthy volunteers
16
8 male and 8 female (non-lactating women )
24, 48, 72, and 96 hours after cocktail administration
Drug or Natural Product Administration
Oral
Furosemide (10 mg/mL solution; West-ward Pharmaceuticals Corp., Eatontown, NJ), metformin (500 mg/5 mL solution; Ranbaxy Pharmaceuticals, Inc., Jacksonville, FL), rosuvastatin (10 mg tablet; Camber Pharmaceuticals Inc., Piscataway, NJ), and midazolam (2 mg/mL syrup; West-ward Pharmaceuticals Corp.)
1 mg furosemide, 50 mg metformin, 10 mg rosuvastatin, and 2.5 mg midazolam
single dose
once
Oral
capsule
3 g
1 g every 4 hours
3 times
Now Foods, Bloomingdale, IL
2019