- Natural product: Goldenseal (Hydrastis canadensis)
- Associated study: Human Cytochrome P450 Inhibition and Metabolic-Intermediate Complex Formation By Goldenseal Extract and Its Methylenedioxyphenyl Components
In Vitro Enzyme Inhibition Experiment
2C9 Inhibition by GS Extract
Inhibition was detected. Cutoff used — not specified
- CYP2C9 4309227
Cell fraction Pooled human liver microsomes -7999662
Results
Fig 2 difference estimate at 1% of extract
Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
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Experimental Conditions
0.5 mg/mL
Commercially available
30 min
NADPH
100 μM
No NADPH with precipitant