- Natural product: Goldenseal (Hydrastis canadensis)
- Associated study: Supplementation With Goldenseal (Hydrastis canadensis), but not Kava Kava (Piper methysticum), Inhibits Human CYP3A Activity In Vivo
In Vivo Interaction Study
CYP3A4 Experiment - MDZ probe
Increased systemic exposure was detected.
midazolam 708298
- CYP3A4 4306811
Results
Control is pre-goldenseal administration
Test is post-goldenseal administration
Data from Table 1/Table 2
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
Multiple dosing
Females
Males
Nonsmokers
16
8 women.
Normal diet, and were not users of botanical dietary supplements; nor were they taking any prescription medications. All female subjects had a negative pregnancy test at baseline, and
0, 0.25, 0.50, 0.75, 1, 1.5, 2, 3, 4, 5, and 6 h
Drug or Natural Product Administration
Oral
Unspecified
8 mg with 240 mL of water
14 days administered 24h before the start of each supplementation/medication phase (baseline) and again on the last day of each phase.
Oral
Capsule
3969 mg
three times daily
14 days
Nautre’s Resource Products
not specified
standardized to contain 24.1 mg isoquinoline alkaloids per capsule