In Vivo Interaction Study
CYP3A4 Experiment - MDZ probe
Increased systemic exposure was detected.
- CYP3A4 4306811
Control is pre-goldenseal administration
Test is post-goldenseal administration
Data from Table 1/Table 2
|Sample||Compound measured||Value||Measurement||Study sequence||Additional information||N replicates|
Normal diet, and were not users of botanical dietary supplements; nor were they taking any prescription medications. All female subjects had a negative pregnancy test at baseline, and
0, 0.25, 0.50, 0.75, 1, 1.5, 2, 3, 4, 5, and 6 h
Drug or Natural Product Administration
8 mg with 240 mL of water
14 days administered 24h before the start of each supplementation/medication phase (baseline) and again on the last day of each phase.
three times daily
Nautre’s Resource Products
standardized to contain 24.1 mg isoquinoline alkaloids per capsule