midazolam
InChIKey: DDLIGBOFAVUZHB-UHFFFAOYSA-N

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ID Subject of Study Study Name Name Type Overall Effect Enzymes Transporters Object Object Metabolite Precipitant
NPDI-AIlkaw Green tea (Camellia sinensis) Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes Inhibition of CYP3A by (-)-Epigallocatechin Gallate in HIM (Ki Determination) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
midazolam 1'-hydroxymidazolam (-)-epigallocatechin gallate
NPDI-FMvj7w Green tea (Camellia sinensis) Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes Inhibition of CYP3A by (-)-Epigallocatechin Gallate in HIM (IC50 Determination) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
midazolam 1'-hydroxymidazolam (-)-epigallocatechin gallate
NPDI-LZlNyQ Green tea (Camellia sinensis) Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes Inhibition of CYP3A by (-)-Epigallocatechin Gallate in HLM (Ki Determination) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
midazolam 1'-hydroxymidazolam (-)-epigallocatechin gallate
NPDI-6x_uKQ Green tea (Camellia sinensis) Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes Inhibition of CYP3A by (-)-Epigallocatechin Gallate in HLM (IC50 Determination) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
midazolam 1'-hydroxymidazolam (-)-epigallocatechin gallate
NPDI-Cuu5WA Green tea (Camellia sinensis) Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450 In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
midazolam 1'-hydroxymidazolam epigallocatechin gallate
NPDI-JGDRVA Green tea (Camellia sinensis) Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450 Percent inhibition of CYP3A4 by epicatechin gallate In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
midazolam 1'-hydroxymidazolam epicatechin gallate
NPDI-j7Vnlw Goldenseal (Hydrastis canadensis) Repeated administration of berberine inhibits cytochromes P450 in humans CYP3A4 Experiment In Vivo Interaction positive — PK Interaction - Increased systemic exposure
  • CYP3A4
midazolam berberine
NPDI-Aw3yIw Goldenseal (Hydrastis canadensis) Supplementation With Goldenseal (Hydrastis canadensis), but not Kava Kava (Piper methysticum), Inhibits Human CYP3A Activity In Vivo CYP3A4 Experiment - MDZ probe In Vivo Interaction positive — PK Interaction - Increased systemic exposure
  • CYP3A4
midazolam goldenseal root extract
NPDI-Bi2fGw Goldenseal (Hydrastis canadensis) In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4 phenotypes CYP3A4 Experiment In Vivo Interaction positive — PK Interaction - Increased systemic exposure
  • CYP3A4
midazolam goldenseal root extract
NPDI-hYXlNQ Goldenseal (Hydrastis canadensis) An ex vivo approach to botanical-drug interactions: A proof of concept study 3A4/5 Inhibition by Goldenseal In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A
midazolam 1'-hydroxymidazolam goldenseal root extract
NPDI-PaRJNQ Goldenseal (Hydrastis canadensis) An ex vivo approach to botanical-drug interactions: A proof of concept study 3A4/5 Inhibition by Berberine (PB) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A
midazolam 1'-hydroxymidazolam berberine
NPDI-6AJ-fg Goldenseal (Hydrastis canadensis) An ex vivo approach to botanical-drug interactions: A proof of concept study 3A4/5 Inhibition by Hydrastine (PB) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A
midazolam 1'-hydroxymidazolam hydrastine
NPDI-KGE4lw Goldenseal (Hydrastis canadensis) An ex vivo approach to botanical-drug interactions: A proof of concept study 3A4/5 Inhibition by Berberine (Plasma) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A
midazolam 1'-hydroxymidazolam berberine
NPDI-gAs6gw Goldenseal (Hydrastis canadensis) An ex vivo approach to botanical-drug interactions: A proof of concept study 3A4/5 Inhibition by Hydrastine (Plasma) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A
midazolam 1'-hydroxymidazolam hydrastine
NPDI-_UID1w Goldenseal (Hydrastis canadensis) An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents 3A4 Inhibition by Hydrastine (MDZ) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
midazolam 1'-hydroxymidazolam hydrastine
NPDI-cnkDpg Goldenseal (Hydrastis canadensis) An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents 3A4 Inhibition by Ethanolic GS Extract (MDZ) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
midazolam 1'-hydroxymidazolam ethanolic goldenseal extract
NPDI-Z0x9xQ Goldenseal (Hydrastis canadensis) An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents 3A4 Inhibition by Aq GS Extract (MDZ) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
midazolam 1'-hydroxymidazolam aqueous goldenseal extract
NPDI-ov597g Kratom (Mitragyna speciosa) Refined Prediction of Pharmacokinetic Kratom-Drug Interactions: Time-Dependent Inhibition Considerations Screening of mitragynine as inhibitors of CYP3A activity in HLM In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A
midazolam 1'-hydroxymidazolam mitragynine
NPDI-7-Gg-g Kratom (Mitragyna speciosa) Refined Prediction of Pharmacokinetic Kratom-Drug Interactions: Time-Dependent Inhibition Considerations Screening of kratom extracts as inhibitors of CYP3A activity in HLM In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A
midazolam 1'-hydroxymidazolam methanolic extract of kratom
NPDI-vr5BAA Kratom (Mitragyna speciosa) Refined Prediction of Pharmacokinetic Kratom-Drug Interactions: Time-Dependent Inhibition Considerations Screening of mitragynine as inhibitors CYP3A activity in HIM In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A
midazolam 1'-hydroxymidazolam mitragynine
NPDI-QbMPuw Kratom (Mitragyna speciosa) Refined Prediction of Pharmacokinetic Kratom-Drug Interactions: Time-Dependent Inhibition Considerations Screening of kratom extracts as inhibitors CYP3A activity in HIM In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A
midazolam 1'-hydroxymidazolam mitragynine
NPDI-515DHw Kratom (Mitragyna speciosa) Refined Prediction of Pharmacokinetic Kratom-Drug Interactions: Time-Dependent Inhibition Considerations Inhibition kinetics of CYP3A activity by mitragynine in HLM In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A
midazolam 1'-hydroxymidazolam mitragynine
NPDI-Tr3Eyg Kratom (Mitragyna speciosa) Refined Prediction of Pharmacokinetic Kratom-Drug Interactions: Time-Dependent Inhibition Considerations Inhibition kinetics of CYP3A activity by mitragynine in HIM In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A
midazolam 1'-hydroxymidazolam mitragynine
NPDI-4_UdSg Kratom (Mitragyna speciosa) Refined Prediction of Pharmacokinetic Kratom-Drug Interactions: Time-Dependent Inhibition Considerations IC50 shift determination for mitragynine towards CYP3A activity in HLM with NADPH In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A
midazolam 1'-hydroxymidazolam mitragynine
NPDI-EjMg0g Kratom (Mitragyna speciosa) Refined Prediction of Pharmacokinetic Kratom-Drug Interactions: Time-Dependent Inhibition Considerations IC50 shift determination for mitragynine towards CYP3A activity in HLM without NADPH In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A
midazolam 1'-hydroxymidazolam mitragynine
NPDI-A66pwQ Kratom (Mitragyna speciosa) Refined Prediction of Pharmacokinetic Kratom-Drug Interactions: Time-Dependent Inhibition Considerations IC50 shift determination for mitragynine towards CYP3A activity in HIM with NADPH In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A
midazolam 1'-hydroxymidazolam mitragynine
NPDI-o8WmjA Kratom (Mitragyna speciosa) Refined Prediction of Pharmacokinetic Kratom-Drug Interactions: Time-Dependent Inhibition Considerations IC50 shift determination for mitragynine towards CYP3A activity in HIM without NADPH In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A
midazolam 1'-hydroxymidazolam mitragynine
NPDI-7z5LQg Licorice (Glycyrrhiza glabra) Cytochrome P450 inhibition by licorice species Glycyrrhiza glabra L. and fourteen licorice constituents Negligible inhibition of CYP3A4 by G. glabra Licorice extract In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP3A4
midazolam 1'-hydroxymidazolam ethanolic extract of licorice g. glabra
NPDI-aX49Ng Licorice (Glycyrrhiza uralensis) Cytochrome P450 inhibition by licorice species Glycyrrhiza uralensis and fourteen licorice constituents Negligible inhibition of CYP3A4 by G. uralensis Licorice extract In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP3A4
midazolam 1'-hydroxymidazolam ethanolic extract of licorice g. uralensis
NPDI-pHgnHQ Licorice (Glycyrrhiza inflata) Cytochrome P450 inhibition by licorice species Glycyrrhiza inflata and fourteen licorice constituents Inhibition of CYP3A4 by G. inflata Licorice extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
midazolam 1'-hydroxymidazolam ethanolic extract of licorice g. inflata
NPDI-CAfs7A licochalcone a Inhibition of CYP enzymes by licochalcone a Inhibition of CYP3A4 by Licochalcone A In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
midazolam 1'-hydroxymidazolam licochalcone a
NPDI-kew9FQ Kratom (Mitragyna speciosa) Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids Control Positive Inhibition for CYP3A4/5 In Vitro Enzyme Inhibition (Control experiment) positive — In Vitro Enzyme Inhibition
  • CYP3A4
  • CYP3A5
midazolam 1'-hydroxymidazolam ketoconazole
NPDI-c_gPeA Kratom (Mitragyna speciosa) Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids Inhibition of Mitragynine for CYP3A4/5 In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
  • CYP3A5
midazolam 1'-hydroxymidazolam mitragynine
NPDI-QQeDSQ Kratom (Mitragyna speciosa) Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids Inhibition of Speciogynine for CYP3A4/5 In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
  • CYP3A5
midazolam 1'-hydroxymidazolam speciogynine
NPDI-TTv3Iw Kratom (Mitragyna speciosa) Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids Inhibition of Speciociliatine for CYP3A4/5 In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
  • CYP3A5
midazolam 1'-hydroxymidazolam speciociliatine
NPDI-7PU97Q Kratom (Mitragyna speciosa) Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids Inhibition of Corynantheidine for CYP3A4/5 In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
  • CYP3A5
midazolam 1'-hydroxymidazolam corynantheidine
NPDI-olaGPQ Kratom (Mitragyna speciosa) Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids Weak Inhibition of 7-hydroxymitragynine for CYP3A4/5 In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP3A4
  • CYP3A5
midazolam 1'-hydroxymidazolam 7-hydroxymitragynine
NPDI-WakYGw Kratom (Mitragyna speciosa) Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids Inhibition of Paynantheine for CYP3A4/5 In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
  • CYP3A5
midazolam 1'-hydroxymidazolam paynantheine
NPDI-DboNmw Goldenseal (Hydrastis canadensis) A clinical study of transporter-mediated goldenseal drug interactions clinical goldenseal - midazolam experiment In Vivo Interaction positive — PK Interaction - Increased systemic exposure
  • CYP3A4
midazolam goldenseal root extract
NPDI-FsyoWg Gou Teng (Uncaria rhynchophylla) Identification of PXR activators from Uncaria rhynchophylla (Gou Teng) Gou Teng 1/2500 Extracts on CYP3A4 Activity In Vitro Enzyme Induction positive — In Vitro Enzyme Induction
  • CYP3A4
midazolam 1'-hydroxymidazolam gou teng extract
NPDI-hg991g Cat's-claw (Uncaria tomentosa) Identification of PXR activators from Uncaria tomentosa (Cat’s Claw) Cat's Claw 1/5000 Extracts on CYP3A4 Activity In Vitro Enzyme Induction positive — In Vitro Enzyme Induction
  • CYP3A4
midazolam 1'-hydroxymidazolam cat's claw extract
NPDI-jUInZg Gou Teng (Uncaria rhynchophylla) Identification of PXR activators from Uncaria rhynchophylla (Gou Teng) Isocorynoxeine on CYP3A4 Activity In Vitro Enzyme Induction positive — In Vitro Enzyme Induction
  • CYP3A4
midazolam 1'-hydroxymidazolam isocorynoxeine
NPDI-scab3g Kratom (Mitragyna speciosa) Clinical Assessment of the Drug Interaction Potential of the Psychotropic Natural Product Kratom kratom tea - midazolam interaction clinical NPDI study In Vivo Interaction positive — PK Interaction - Increased systemic exposure
  • CYP3A4
midazolam water extract of kratom
NPDI-cyF5-w Gou Teng (Uncaria rhynchophylla) Identification of PXR activators from Uncaria rhynchophylla (Gou Teng) Gou Teng 1/500 Extracts on CYP3A4 Activity In Vitro Enzyme Induction positive — In Vitro Enzyme Induction
  • CYP3A4
midazolam 1'-hydroxymidazolam gou teng extract
NPDI-lVB-wQ Gou Teng (Uncaria rhynchophylla) Identification of PXR activators from Uncaria rhynchophylla (Gou Teng) Gou Teng 1/250 Extracts on CYP3A4 Activity In Vitro Enzyme Induction positive — In Vitro Enzyme Induction
  • CYP3A4
midazolam 1'-hydroxymidazolam gou teng extract
NPDI-irr70Q Gou Teng (Uncaria rhynchophylla) Identification of PXR activators from Uncaria rhynchophylla (Gou Teng) Gou Teng 1/100 Extracts on CYP3A4 Activity In Vitro Enzyme Induction positive — In Vitro Enzyme Induction
  • CYP3A4
midazolam 1'-hydroxymidazolam gou teng extract
NPDI-sfIKSQ Gou Teng (Uncaria rhynchophylla) Identification of PXR activators from Uncaria rhynchophylla (Gou Teng) Gou Teng 1/50 Extracts on CYP3A4 Activity In Vitro Enzyme Induction positive — In Vitro Enzyme Induction
  • CYP3A4
midazolam 1'-hydroxymidazolam gou teng extract
NPDI-VZwgtA Gou Teng (Uncaria rhynchophylla) Identification of PXR activators from Uncaria rhynchophylla (Gou Teng) Rhynchophylline on CYP3A4 Activity In Vitro Enzyme Induction positive — In Vitro Enzyme Induction
  • CYP3A4
midazolam 1'-hydroxymidazolam rhynchophylline
NPDI-3oSxuQ Gou Teng (Uncaria rhynchophylla) Identification of PXR activators from Uncaria rhynchophylla (Gou Teng) Isorhynchophylline on CYP3A4 Activity In Vitro Enzyme Induction positive — In Vitro Enzyme Induction
  • CYP3A4
midazolam 1'-hydroxymidazolam isorhynchophylline
NPDI-D-IVFw Gou Teng (Uncaria rhynchophylla) Identification of PXR activators from Uncaria rhynchophylla (Gou Teng) Corynoxeine on CYP3A4 Activity In Vitro Enzyme Induction positive — In Vitro Enzyme Induction
  • CYP3A4
midazolam 1'-hydroxymidazolam corynoxeine
NPDI-NxBuuA Cat's-claw (Uncaria tomentosa) Identification of PXR activators from Uncaria tomentosa (Cat’s Claw) Cat's Claw 1/2500 Extracts on CYP3A4 Activity In Vitro Enzyme Induction positive — In Vitro Enzyme Induction
  • CYP3A4
midazolam 1'-hydroxymidazolam cat's claw extract
NPDI-h8CxDA Cat's-claw (Uncaria tomentosa) Identification of PXR activators from Uncaria tomentosa (Cat’s Claw) Cat's Claw 1/1000 Extracts on CYP3A4 Activity In Vitro Enzyme Induction positive — In Vitro Enzyme Induction
  • CYP3A4
midazolam 1'-hydroxymidazolam cat's claw extract
NPDI-nRt2ng Cat's-claw (Uncaria tomentosa) Identification of PXR activators from Uncaria tomentosa (Cat’s Claw) Cat's Claw 1/500 Extracts on CYP3A4 Activity In Vitro Enzyme Induction positive — In Vitro Enzyme Induction
  • CYP3A4
midazolam 1'-hydroxymidazolam cat's claw extract
NPDI-McqRuA Cat's-claw (Uncaria tomentosa) Identification of PXR activators from Uncaria tomentosa (Cat’s Claw) Mitraphylline on CYP3A4 Activity In Vitro Enzyme Induction positive — In Vitro Enzyme Induction
  • CYP3A4
midazolam 1'-hydroxymidazolam mitraphylline
NPDI-bb32sA Cat's-claw (Uncaria tomentosa) Identification of PXR activators from Uncaria tomentosa (Cat’s Claw) Pteropodine on CYP3A4 Activity In Vitro Enzyme Induction positive — In Vitro Enzyme Induction
  • CYP3A4
midazolam 1'-hydroxymidazolam pteropodine
NPDI-SZr2oA Cat's-claw (Uncaria tomentosa) Identification of PXR activators from Uncaria tomentosa (Cat’s Claw) Isopteropodine on CYP3A4 Activity In Vitro Enzyme Induction positive — In Vitro Enzyme Induction
  • CYP3A4
midazolam 1'-hydroxymidazolam isopteropodine
NPDI-d2rDLg Cannabis (Cannabis sativa) Drug Approval Package: Epidiolex (Cannabidiol) CBD Effect on Midazolam In Vivo Interaction negative — No Effect (based on bioequivalence limits)
midazolam cannabidiol
ID Subject of Study Name
NPDI-aujB5A Green tea (Camellia sinensis) Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes
NPDI-dCfz1g Green tea (Camellia sinensis) Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450
NPDI-5XFThQ Goldenseal (Hydrastis canadensis) Repeated administration of berberine inhibits cytochromes P450 in humans
NPDI-twVQgQ Goldenseal (Hydrastis canadensis) Supplementation With Goldenseal (Hydrastis canadensis), but not Kava Kava (Piper methysticum), Inhibits Human CYP3A Activity In Vivo
NPDI-ftEv0g Goldenseal (Hydrastis canadensis) In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4 phenotypes
NPDI-luckpg Goldenseal (Hydrastis canadensis) An ex vivo approach to botanical-drug interactions: A proof of concept study
NPDI-EiXGKA Goldenseal (Hydrastis canadensis) An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents
NPDI-d8OUzg Kratom (Mitragyna speciosa) Refined Prediction of Pharmacokinetic Kratom-Drug Interactions: Time-Dependent Inhibition Considerations
NPDI-8SkM4A Licorice (Glycyrrhiza glabra) Cytochrome P450 inhibition by licorice species Glycyrrhiza glabra L. and fourteen licorice constituents
NPDI-Lm3PvA Licorice (Glycyrrhiza uralensis) Cytochrome P450 inhibition by licorice species Glycyrrhiza uralensis and fourteen licorice constituents
NPDI-UmIRAQ Licorice (Glycyrrhiza inflata) Cytochrome P450 inhibition by licorice species Glycyrrhiza inflata and fourteen licorice constituents
NPDI-oEAKVw licochalcone a Inhibition of CYP enzymes by licochalcone a
NPDI-eReNjw Kratom (Mitragyna speciosa) Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids
NPDI-O4gNrA Goldenseal (Hydrastis canadensis) A clinical study of transporter-mediated goldenseal drug interactions
NPDI-O6q4mg Gou Teng (Uncaria rhynchophylla) Identification of PXR activators from Uncaria rhynchophylla (Gou Teng)
NPDI--UmauA Cat's-claw (Uncaria tomentosa) Identification of PXR activators from Uncaria tomentosa (Cat’s Claw)
NPDI-osTXuQ Kratom (Mitragyna speciosa) Clinical Assessment of the Drug Interaction Potential of the Psychotropic Natural Product Kratom
NPDI-SiYA_A Cannabis (Cannabis sativa) Drug Approval Package: Epidiolex (Cannabidiol)

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