3A4/5 Inhibition by Hydrastine (Plasma) CSV JSON

In Vitro Enzyme Inhibition Experiment

3A4/5 Inhibition by Hydrastine (Plasma)

Inhibition was detected.  Cutoff used — not specified

midazolam 708298

hydrastine

1'-hydroxymidazolam

  • CYP3A

Cell fraction Pooled human liver microsomes -7999662

Results

300 μM estimate from Fig 6
Fig 4a in parentheses

Compound measured Measurement Value Study sequence Additional information N replicates

Experimental Conditions

0.2 mg/ml

80 μl

10 min

NADPH regenerating system

10 μM

10 min

3, 10, 30, 100, 300 μM