- Natural product: Goldenseal (Hydrastis canadensis)
- Associated study: An ex vivo approach to botanical-drug interactions: A proof of concept study
In Vitro Enzyme Inhibition Experiment
3A4/5 Inhibition by Hydrastine (Plasma)
Inhibition was detected. Cutoff used — not specified
- CYP3A
Cell fraction Pooled human liver microsomes -7999662
Results
300 μM estimate from Fig 6
Fig 4a in parentheses
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
0.2 mg/ml
80 μl
10 min
NADPH regenerating system
10 μM
10 min
3, 10, 30, 100, 300 μM