hydrastine
InChIKey: JZUTXVTYJDCMDU-MOPGFXCFSA-N

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Compound information managed by NaPDI

  • Goldenseal (Hydrastis canadensis)

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ID Subject of Study Study Name Name Type Overall Effect Enzymes Transporters Object Object Metabolite Precipitant
NPDI-6AJ-fg Goldenseal (Hydrastis canadensis) An ex vivo approach to botanical-drug interactions: A proof of concept study 3A4/5 Inhibition by Hydrastine (PB) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A
midazolam 1'-hydroxymidazolam hydrastine
NPDI-gAs6gw Goldenseal (Hydrastis canadensis) An ex vivo approach to botanical-drug interactions: A proof of concept study 3A4/5 Inhibition by Hydrastine (Plasma) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A
midazolam 1'-hydroxymidazolam hydrastine
NPDI-aGqWbw Goldenseal (Hydrastis canadensis) Effects of Herbal Products and their Constituents on Human Cytochrome P4502E1 Activity 2E1 Inhibition by Hydrastine In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2E1
p-nitrophenol 4-nitrophenyl sulfate hydrastine
NPDI-VqNO0Q Goldenseal (Hydrastis canadensis) An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents 2C8 Inhibition by Hydrastine In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C8
paclitaxel 6-alpha-hydroxy paclitaxel hydrastine
NPDI-6gn9Dg Goldenseal (Hydrastis canadensis) An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents 2D6 Inhibition by Hydrastine In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2D6
dextromethorphan dextrorphan hydrastine
NPDI-NNibEQ Goldenseal (Hydrastis canadensis) An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents 2E1 Inhibition by Hydrastine In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2E1
p-nitrophenol 4-nitrophenyl sulfate hydrastine
NPDI-_UID1w Goldenseal (Hydrastis canadensis) An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents 3A4 Inhibition by Hydrastine (MDZ) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
midazolam 1'-hydroxymidazolam hydrastine
NPDI-5wiIYg Goldenseal (Hydrastis canadensis) An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents 3A4 Inhibition by Hydrastine (Testosterone) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
testosterone 6beta-hydroxytestosterone hydrastine
NPDI-59mQTg Goldenseal (Hydrastis canadensis) An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents 1A2 Inhibition by Hydrastine In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A2
acetanilide acetaminophen hydrastine
NPDI-dgm1Ww Goldenseal (Hydrastis canadensis) An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents 2C9 Inhibition by Hydrastine In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2C9
tolbutamide hydroxymethyltolbutamide hydrastine
NPDI-6cuc3g Goldenseal (Hydrastis canadensis) An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents 2C19 Inhibition by Hydrastine In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- hydrastine
NPDI-w-6ghw Goldenseal (Hydrastis canadensis) Human Cytochrome P450 Inhibition and Metabolic-Intermediate Complex Formation By Goldenseal Extract and Its Methylenedioxyphenyl Components 2D6 Inhibition by (+) Hydrastine In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
bufuralol 1'-hydroxybufuralol hydrastine
NPDI-39rhWg Goldenseal (Hydrastis canadensis) Human Cytochrome P450 Inhibition and Metabolic-Intermediate Complex Formation By Goldenseal Extract and Its Methylenedioxyphenyl Components 3A4 Inhibition by (+) Hydrastine In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
testosterone 6beta-hydroxytestosterone hydrastine
NPDI-3M10oA Goldenseal (Hydrastis canadensis) Human Cytochrome P450 Inhibition and Metabolic-Intermediate Complex Formation By Goldenseal Extract and Its Methylenedioxyphenyl Components 2C9 Inhibition by (+) Hydrastine In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
diclofenac 4'-hydroxydiclofenac hydrastine
NPDI-9t7UTw Goldenseal (Hydrastis canadensis) Goldenseal Characterization of Material Goldenseal Characterization of Material Experiment Characterization of Material

Compound information from external resources

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