- Natural product: Goldenseal (Hydrastis canadensis)
- Associated study: An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents
In Vitro Enzyme Inhibition Experiment
2C8 Inhibition by Hydrastine
Inhibition was detected. Cutoff used — not specified
- CYP2C8 4306333
Cell fraction Pooled human liver microsomes -7999662
Results
Estimate of inhibition Fig 1 at 20 μM
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
In-house preparation
HHM-247 and HHM-258
15 min
NADPH
10 min
No NADPH with precipitant
1 or 20 μM