- Natural product: Goldenseal (Hydrastis canadensis)
- Associated study: Human Cytochrome P450 Inhibition and Metabolic-Intermediate Complex Formation By Goldenseal Extract and Its Methylenedioxyphenyl Components
In Vitro Enzyme Inhibition Experiment
2C9 Inhibition by (+) Hydrastine
Inhibition was detected. Cutoff used — not specified
- CYP2C9 4309227
Cell fraction Pooled human liver microsomes -7999662
Results
Fig 4c at 1000 μM
Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
---|
Experimental Conditions
0.5 mg/mL
Commercially available
30 min
NADPH
100 μM
No NADPH with precipitant
10, 100, and 1000 μM