hydroxymethyltolbutamide
InChIKey: SJRHYONYKZIRPM-UHFFFAOYSA-N

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Compound information managed by NaPDI


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ID Subject of Study Study Name Name Type Overall Effect Enzymes Transporters Object Object Metabolite Precipitant
NPDI-AVsEiw licochalcone a Inhibition of CYP enzymes by licochalcone a Inhibition of CYP2C9 by Licochalcone A In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
tolbutamide hydroxymethyltolbutamide licochalcone a
NPDI-lFzdxg isoliquiritigenin Inhibition of CYP enzymes by isoliquiritigenin Inhibition of CYP2C9 by Isoliquiritigenin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
tolbutamide hydroxymethyltolbutamide isoliquiritigenin
NPDI-AJngcQ glycycoumarin Inhibition of CYP enzymes by glycycoumarin Inhibition of CYP2C9 by Glycycoumarin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
tolbutamide hydroxymethyltolbutamide glycycoumarin
NPDI-Y7VPTg Licorice (Glycyrrhiza inflata) Cytochrome P450 inhibition by licorice species Glycyrrhiza inflata and fourteen licorice constituents Inhibition of CYP2C9 by G. inflata Licorice extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
tolbutamide hydroxymethyltolbutamide ethanolic extract of licorice g. inflata
NPDI-SyZKkg Licorice (Glycyrrhiza uralensis) Cytochrome P450 inhibition by licorice species Glycyrrhiza uralensis and fourteen licorice constituents Inhibition of CYP2C9 by G. uralensis Licorice extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
tolbutamide hydroxymethyltolbutamide ethanolic extract of licorice g. uralensis
NPDI-fbIOUw licoricidin Inhibition of CYP enzymes by licoricidin Inhibition of CYP2C9 by Licoricidin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
tolbutamide hydroxymethyltolbutamide licoricidin
NPDI-1ZgdSQ Licorice (Glycyrrhiza glabra) Cytochrome P450 inhibition by licorice species Glycyrrhiza glabra L. and fourteen licorice constituents Inhibition of CYP2C9 by G. glabra Licorice extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
tolbutamide hydroxymethyltolbutamide ethanolic extract of licorice g. glabra
NPDI-uBMfpQ Goldenseal (Hydrastis canadensis) An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents 2C9 Inhibition by Ethanolic GS Extract In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2C9
tolbutamide hydroxymethyltolbutamide ethanolic goldenseal extract
NPDI-dgm1Ww Goldenseal (Hydrastis canadensis) An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents 2C9 Inhibition by Hydrastine In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2C9
tolbutamide hydroxymethyltolbutamide hydrastine

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