NaPDI | Compound details

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Natural products containing this compound

Enantiomer of compound
None listed

Compound has enantiomers
None listed

Metabolite of compounds

tolbutamide

Compound has metabolites
None listed

ID	Subject of Study	Study Name	Name	Type	Overall Effect	Enzymes	Transporters	Object	Object Metabolite	Precipitant
NPDI-fbIOUw	licoricidin	Inhibition of CYP enzymes by licoricidin	Inhibition of CYP2C9 by Licoricidin	In Vitro Enzyme Inhibition	positive — In Vitro Enzyme Inhibition	CYP2C9		tolbutamide	hydroxymethyltolbutamide	licoricidin
NPDI-1ZgdSQ	Licorice (Glycyrrhiza glabra)	Cytochrome P450 inhibition by licorice species Glycyrrhiza glabra L. and fourteen licorice constituents	Inhibition of CYP2C9 by G. glabra Licorice extract	In Vitro Enzyme Inhibition	positive — In Vitro Enzyme Inhibition	CYP2C9		tolbutamide	hydroxymethyltolbutamide	ethanolic extract of licorice g. glabra
NPDI-SyZKkg	Licorice (Glycyrrhiza uralensis)	Cytochrome P450 inhibition by licorice species Glycyrrhiza uralensis and fourteen licorice constituents	Inhibition of CYP2C9 by G. uralensis Licorice extract	In Vitro Enzyme Inhibition	positive — In Vitro Enzyme Inhibition	CYP2C9		tolbutamide	hydroxymethyltolbutamide	ethanolic extract of licorice g. uralensis
NPDI-Y7VPTg	Licorice (Glycyrrhiza inflata)	Cytochrome P450 inhibition by licorice species Glycyrrhiza inflata and fourteen licorice constituents	Inhibition of CYP2C9 by G. inflata Licorice extract	In Vitro Enzyme Inhibition	positive — In Vitro Enzyme Inhibition	CYP2C9		tolbutamide	hydroxymethyltolbutamide	ethanolic extract of licorice g. inflata
NPDI-uBMfpQ	Goldenseal (Hydrastis canadensis)	An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents	2C9 Inhibition by Ethanolic GS Extract	In Vitro Enzyme Inhibition	negative — In Vitro Enzyme Negligible Inhibition	CYP2C9		tolbutamide	hydroxymethyltolbutamide	ethanolic goldenseal extract
NPDI-dgm1Ww	Goldenseal (Hydrastis canadensis)	An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents	2C9 Inhibition by Hydrastine	In Vitro Enzyme Inhibition	negative — In Vitro Enzyme Negligible Inhibition	CYP2C9		tolbutamide	hydroxymethyltolbutamide	hydrastine
NPDI-AJngcQ	glycycoumarin	Inhibition of CYP enzymes by glycycoumarin	Inhibition of CYP2C9 by Glycycoumarin	In Vitro Enzyme Inhibition	positive — In Vitro Enzyme Inhibition	CYP2C9		tolbutamide	hydroxymethyltolbutamide	glycycoumarin
NPDI-lFzdxg	isoliquiritigenin	Inhibition of CYP enzymes by isoliquiritigenin	Inhibition of CYP2C9 by Isoliquiritigenin	In Vitro Enzyme Inhibition	positive — In Vitro Enzyme Inhibition	CYP2C9		tolbutamide	hydroxymethyltolbutamide	isoliquiritigenin
NPDI-AVsEiw	licochalcone a	Inhibition of CYP enzymes by licochalcone a	Inhibition of CYP2C9 by Licochalcone A	In Vitro Enzyme Inhibition	positive — In Vitro Enzyme Inhibition	CYP2C9		tolbutamide	hydroxymethyltolbutamide	licochalcone a

ID	Subject of Study	Name
NPDI-qiyzaQ	licoricidin	Inhibition of CYP enzymes by licoricidin
NPDI-8SkM4A	Licorice (Glycyrrhiza glabra)	Cytochrome P450 inhibition by licorice species Glycyrrhiza glabra L. and fourteen licorice constituents
NPDI-Lm3PvA	Licorice (Glycyrrhiza uralensis)	Cytochrome P450 inhibition by licorice species Glycyrrhiza uralensis and fourteen licorice constituents
NPDI-UmIRAQ	Licorice (Glycyrrhiza inflata)	Cytochrome P450 inhibition by licorice species Glycyrrhiza inflata and fourteen licorice constituents
NPDI-EiXGKA	Goldenseal (Hydrastis canadensis)	An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents
NPDI-l4wD_A	glycycoumarin	Inhibition of CYP enzymes by glycycoumarin
NPDI-bQlJCA	isoliquiritigenin	Inhibition of CYP enzymes by isoliquiritigenin
NPDI-oEAKVw	licochalcone a	Inhibition of CYP enzymes by licochalcone a

Compound information from external resources

Resource	Identifier
Google search	SJRHYONYKZIRPM-UHFFFAOYSA-N