Licorice (Glycyrrhiza glabra)

Full Name: Glycyrrhiza glabra L.
Kingdom: Plantae
Order: Fabales
Family Name: Fabaceae
Latin Binomial: Glycyrrhiza glabra
Common Names: Guang guo gan cao, Licorice and Liquorice

Natural Product Information From GSRS

Resource Identifier
= Induction
= Inhibition
= No overall effect

Published in vitro enzyme experiments

ethanolic extract of licorice g. glabra
CYP2B6
CYP2C8
CYP2C9
CYP2C19
CYP3A4
CYP1A2
CYP2A6
CYP2D6
CYP2E1

Chemical characterization

liquiritin isoliquiritin licuraside liquiritigenin isoliquiritigenin glycyrrhizin glabridin glycyrrhetinic acid p-hydroxy-benzylmalonic acid (hbma) isoliquiritin apioside liquiritin apioside
Chemical characterization of Licorice, Glycyrrhiza glabra L. 0.31 ± 0 % 0.07 ± 0 % 1.25 ± 0 % 0.07 ± 0 % 0.05 ± 0 % 0.55 ± 0 % 0.46 ± 0 % 0.03 ± 0 % 3.45 ± 0 % 2.52 ± 0 % 9.1 ± 0 %




Data points represent the following samples (click to show/hide):

ID Subject of Study Study Name Name Type Overall Effect Enzymes Transporters Object Object Metabolite Precipitant
NPDI-XhhVrA Licorice (Glycyrrhiza glabra) Cytochrome P450 inhibition by licorice species Glycyrrhiza glabra L. and fourteen licorice constituents Chemical characterization of Licorice, Glycyrrhiza glabra L. Characterization of Material
NPDI-DVoeXQ Licorice (Glycyrrhiza glabra) Cytochrome P450 inhibition by licorice species Glycyrrhiza glabra L. and fourteen licorice constituents Inhibition of CYP2B6 by G. glabra Licorice extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2B6
bupropion hydroxybupropion ethanolic extract of licorice g. glabra
NPDI-TGg2kA Licorice (Glycyrrhiza glabra) Cytochrome P450 inhibition by licorice species Glycyrrhiza glabra L. and fourteen licorice constituents Inhibition of CYP2C8 by G. glabra Licorice extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C8
amodiaquine n-desethylamodiaquine ethanolic extract of licorice g. glabra
NPDI-1ZgdSQ Licorice (Glycyrrhiza glabra) Cytochrome P450 inhibition by licorice species Glycyrrhiza glabra L. and fourteen licorice constituents Inhibition of CYP2C9 by G. glabra Licorice extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
tolbutamide hydroxymethyltolbutamide ethanolic extract of licorice g. glabra
NPDI-DtSHuA Licorice (Glycyrrhiza glabra) Cytochrome P450 inhibition by licorice species Glycyrrhiza glabra L. and fourteen licorice constituents Inhibition of CYP2C19 by G. glabra Licorice extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- ethanolic extract of licorice g. glabra
NPDI-itM3Yw Licorice (Glycyrrhiza glabra) Cytochrome P450 inhibition by licorice species Glycyrrhiza glabra L. and fourteen licorice constituents Inhibition of CYP3A4 by G. glabra Licorice extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
testosterone 6beta-hydroxytestosterone ethanolic extract of licorice g. glabra
NPDI-7z5LQg Licorice (Glycyrrhiza glabra) Cytochrome P450 inhibition by licorice species Glycyrrhiza glabra L. and fourteen licorice constituents Negligible inhibition of CYP3A4 by G. glabra Licorice extract In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP3A4
midazolam 1'-hydroxymidazolam ethanolic extract of licorice g. glabra
NPDI-YywAOQ Licorice (Glycyrrhiza glabra) Cytochrome P450 inhibition by licorice species Glycyrrhiza glabra L. and fourteen licorice constituents Inhibition of CYP1A2 by G. glabra Licorice extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A2
phenacetin acetaminophen ethanolic extract of licorice g. glabra
NPDI-0hKwgw Licorice (Glycyrrhiza glabra) Cytochrome P450 inhibition by licorice species Glycyrrhiza glabra L. and fourteen licorice constituents Negligible inhibition of CYP2A6 by G. glabra Licorice extract In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2A6
coumarin 7-hydroxycoumarin ethanolic extract of licorice g. glabra
NPDI-d_tXmg Licorice (Glycyrrhiza glabra) Cytochrome P450 inhibition by licorice species Glycyrrhiza glabra L. and fourteen licorice constituents Negligible inhibition of CYP2D6 by G. glabra Licorice extract In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2D6
dextromethorphan dextrorphan ethanolic extract of licorice g. glabra
NPDI-QkbxIg Licorice (Glycyrrhiza glabra) Cytochrome P450 inhibition by licorice species Glycyrrhiza glabra L. and fourteen licorice constituents Negligible inhibition of CYP2E1 by G. glabra Licorice extract In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2E1
chloroxazone 6-hydroxychloroxazone ethanolic extract of licorice g. glabra
NPDI-TRV9kg Licorice (Glycyrrhiza glabra) Licorice root extract Nuclear Receptor Induction study - Ole Miss Licorice - In Vitro Nuclear Receptor Induction PXR Experiment - 1 In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • Pregnane X receptor (PXR)
licorice extract
NPDI-WMjqqA Licorice (Glycyrrhiza glabra) Licorice root extract Nuclear Receptor Induction study - Ole Miss Licorice - In Vitro Nuclear Receptor Induction PXR Experiment - 2 In Vitro Nuclear Receptor Induction negative — In Vitro Nuclear Receptor Non-induction
  • Pregnane X receptor (PXR)
licorice extract
NPDI-LMJ6xw Licorice (Glycyrrhiza glabra) Licorice root extract Nuclear Receptor Induction study - Ole Miss Licorice - In Vitro Nuclear Receptor Induction PXR Experiment - 3 In Vitro Nuclear Receptor Induction negative — In Vitro Nuclear Receptor Non-induction
  • Pregnane X receptor (PXR)
licorice extract
NPDI-j_iwWA Licorice (Glycyrrhiza glabra) Licorice root extract Nuclear Receptor Induction study - Ole Miss Licorice - In Vitro Nuclear Receptor Induction AHR Experiment - 1 In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • Aryl hydrocarbon receptor (AHR)
licorice extract
NPDI-ecv2pw Licorice (Glycyrrhiza glabra) Licorice root extract Nuclear Receptor Induction study - Ole Miss Licorice - In Vitro Nuclear Receptor Induction AHR Experiment - 2 In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • Aryl hydrocarbon receptor (AHR)
licorice extract
NPDI-kSnQyg Licorice (Glycyrrhiza glabra) Licorice root extract Nuclear Receptor Induction study - Ole Miss Licorice - In Vitro Nuclear Receptor Induction AHR Experiment - 3 In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • Aryl hydrocarbon receptor (AHR)
licorice extract
NPDI-2aN3fA Licorice (Glycyrrhiza glabra) Chemical basis of pregnane X receptor activators in the herbal supplement Gancao (licorice) Gancao - hPXR Activation Experiment - 1 In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • Pregnane X receptor (PXR)
gancao extract
NPDI-fdQymA Licorice (Glycyrrhiza glabra) Chemical basis of pregnane X receptor activators in the herbal supplement Gancao (licorice) Gancao 1:1000 - hPXR Activation Experiment - 1 In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • Pregnane X receptor (PXR)
gancao extract
NPDI-uTdxOg Licorice (Glycyrrhiza glabra) Chemical basis of pregnane X receptor activators in the herbal supplement Gancao (licorice) Gancao 1:800 - hPXR Activation Experiment - 2 In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • Pregnane X receptor (PXR)
gancao extract
NPDI-yaDA9A Licorice (Glycyrrhiza glabra) Chemical basis of pregnane X receptor activators in the herbal supplement Gancao (licorice) Gancao 1:400 - hPXR Activation Experiment - 3 In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • Pregnane X receptor (PXR)
gancao extract
NPDI-6k7lVQ Licorice (Glycyrrhiza glabra) Chemical basis of pregnane X receptor activators in the herbal supplement Gancao (licorice) Gancao 1:200 - hPXR Activation Experiment - 4 In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • Pregnane X receptor (PXR)
gancao extract
NPDI-tsyNWQ Licorice (Glycyrrhiza glabra) Chemical basis of pregnane X receptor activators in the herbal supplement Gancao (licorice) Gancao 1:100 - hPXR Activation Experiment - 5 In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • Pregnane X receptor (PXR)
gancao extract
NPDI-oJ9-pA Licorice (Glycyrrhiza glabra) Chemical basis of pregnane X receptor activators in the herbal supplement Gancao (licorice) Esculetin - hPXR Activation Experiment - 1 In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • Pregnane X receptor (PXR)
esculetin
NPDI-V1A9Uw Licorice (Glycyrrhiza glabra) Chemical basis of pregnane X receptor activators in the herbal supplement Gancao (licorice) Glabrol - hPXR Activation Experiment - 1 In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • Pregnane X receptor (PXR)
glabrol
NPDI-3xuV4Q Licorice (Glycyrrhiza glabra) Chemical basis of pregnane X receptor activators in the herbal supplement Gancao (licorice) Licochalcone B - hPXR Activation Experiment - 1 In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • Pregnane X receptor (PXR)
licochalcone b
NPDI-JEa8WA Licorice (Glycyrrhiza glabra) Chemical basis of pregnane X receptor activators in the herbal supplement Gancao (licorice) Glabridin - hPXR Activation Experiment - 1 In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • Pregnane X receptor (PXR)
glabridin
NPDI-VwDDFg Licorice (Glycyrrhiza glabra) Chemical basis of pregnane X receptor activators in the herbal supplement Gancao (licorice) Isoliquiritigenin - hPXR Activation Experiment - 1 In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • Pregnane X receptor (PXR)
isoliquiritigenin
NPDI-bJS_nw Licorice (Glycyrrhiza glabra) Chemical basis of pregnane X receptor activators in the herbal supplement Gancao (licorice) Isoliquiritin - hPXR Activation Experiment - 1 In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • Pregnane X receptor (PXR)
isoliquiritin
NPDI-BPK0rg Licorice (Glycyrrhiza glabra) Chemical basis of pregnane X receptor activators in the herbal supplement Gancao (licorice) Liquiritigenin - hPXR Activation Experiment - 1 In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • Pregnane X receptor (PXR)
liquiritigenin
NPDI-fCU6fg Licorice (Glycyrrhiza glabra) Chemical basis of pregnane X receptor activators in the herbal supplement Gancao (licorice) Glycyrrhetinic acid - hPXR Activation Experiment - 1 In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • Pregnane X receptor (PXR)
glycyrrhetinic acid
NPDI-xEliuw Licorice (Glycyrrhiza glabra) Chemical basis of pregnane X receptor activators in the herbal supplement Gancao (licorice) Liquiritin - hPXR Activation Experiment - 1 In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • Pregnane X receptor (PXR)
liquiritin
NPDI-kYQYbw Licorice (Glycyrrhiza glabra) Chemical basis of pregnane X receptor activators in the herbal supplement Gancao (licorice) Glycyrrhizin - hPXR Activation Experiment - 1 In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • Pregnane X receptor (PXR)
glycyrrhizin
NPDI-fwE-hQ Licorice (Glycyrrhiza glabra) Chemical basis of pregnane X receptor activators in the herbal supplement Gancao (licorice) Liquiritin apioside hPXR Activation Experiment - 1 In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • Pregnane X receptor (PXR)
liquiritin apioside
NPDI-Ik84yA Licorice (Glycyrrhiza glabra) Chemical basis of pregnane X receptor activators in the herbal supplement Gancao (licorice) Glycyrrhetinic acid - CAR Activation Experiment - 1 In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • Pregnane X receptor (PXR)
glycyrrhetinic acid
NPDI-BSD3Hg Licorice (Glycyrrhiza glabra) Chemical basis of pregnane X receptor activators in the herbal supplement Gancao (licorice) Glycyrrhetinic acid - GR Activation Experiment - 1 In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • Pregnane X receptor (PXR)
glycyrrhetinic acid
NPDI-OihIuQ Licorice (Glycyrrhiza glabra) Chemical basis of pregnane X receptor activators in the herbal supplement Gancao (licorice) Metabolomic Profiling of Gancao Phytoconstituents Metabolomics