Licorice (Glycyrrhiza glabra)

Full Name: Glycyrrhiza glabra L.
Kingdom: Plantae
Order: Fabales
Family Name: Fabaceae
Latin Binomial: Glycyrrhiza glabra
Common Names: Guang guo gan cao, Licorice and Liquorice

Natural Product Information From GSRS

Resource Identifier
= Induction
= Inhibition
= No overall effect

Published in vitro enzyme experiments

ethanolic extract of licorice g. glabra
CYP1A2
CYP3A4
CYP2C8
CYP2B6
CYP2C9
CYP2E1
CYP2A6
CYP2D6
CYP2C19

Chemical characterization

glabridin glycyrrhetinic acid glycyrrhizin isoliquiritigenin isoliquiritin isoliquiritin apioside licuraside liquiritigenin liquiritin p-hydroxy-benzylmalonic acid (hbma) liquiritin apioside
Chemical characterization of Licorice, Glycyrrhiza glabra L. 0.46 ± 0 % 0.03 ± 0 % 0.55 ± 0 % 0.05 ± 0 % 0.07 ± 0 % 2.52 ± 0 % 1.25 ± 0 % 0.07 ± 0 % 0.31 ± 0 % 3.45 ± 0 % 9.1 ± 0 %
ID Subject of Study Study Name Name Type Overall Effect Enzymes Transporters Object Object Metabolite Precipitant
NPDI-XhhVrA Licorice (Glycyrrhiza glabra) Cytochrome P450 inhibition by licorice species Glycyrrhiza glabra L. and fourteen licorice constituents Chemical characterization of Licorice, Glycyrrhiza glabra L. Characterization of Material
NPDI-YywAOQ Licorice (Glycyrrhiza glabra) Cytochrome P450 inhibition by licorice species Glycyrrhiza glabra L. and fourteen licorice constituents Inhibition of CYP1A2 by G. glabra Licorice extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A2
phenacetin acetaminophen ethanolic extract of licorice g. glabra
NPDI-itM3Yw Licorice (Glycyrrhiza glabra) Cytochrome P450 inhibition by licorice species Glycyrrhiza glabra L. and fourteen licorice constituents Inhibition of CYP3A4 by G. glabra Licorice extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
testosterone 6beta-hydroxytestosterone ethanolic extract of licorice g. glabra
NPDI-TGg2kA Licorice (Glycyrrhiza glabra) Cytochrome P450 inhibition by licorice species Glycyrrhiza glabra L. and fourteen licorice constituents Inhibition of CYP2C8 by G. glabra Licorice extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C8
amodiaquine n-desethylamodiaquine ethanolic extract of licorice g. glabra
NPDI-DVoeXQ Licorice (Glycyrrhiza glabra) Cytochrome P450 inhibition by licorice species Glycyrrhiza glabra L. and fourteen licorice constituents Inhibition of CYP2B6 by G. glabra Licorice extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2B6
bupropion hydroxybupropion ethanolic extract of licorice g. glabra
NPDI-1ZgdSQ Licorice (Glycyrrhiza glabra) Cytochrome P450 inhibition by licorice species Glycyrrhiza glabra L. and fourteen licorice constituents Inhibition of CYP2C9 by G. glabra Licorice extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
tolbutamide hydroxymethyltolbutamide ethanolic extract of licorice g. glabra
NPDI-QkbxIg Licorice (Glycyrrhiza glabra) Cytochrome P450 inhibition by licorice species Glycyrrhiza glabra L. and fourteen licorice constituents Negligible inhibition of CYP2E1 by G. glabra Licorice extract In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2E1
chloroxazone 6-hydroxychloroxazone ethanolic extract of licorice g. glabra
NPDI-0hKwgw Licorice (Glycyrrhiza glabra) Cytochrome P450 inhibition by licorice species Glycyrrhiza glabra L. and fourteen licorice constituents Negligible inhibition of CYP2A6 by G. glabra Licorice extract In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2A6
coumarin 7-hydroxycoumarin ethanolic extract of licorice g. glabra
NPDI-7z5LQg Licorice (Glycyrrhiza glabra) Cytochrome P450 inhibition by licorice species Glycyrrhiza glabra L. and fourteen licorice constituents Negligible inhibition of CYP3A4 by G. glabra Licorice extract In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP3A4
midazolam 1'-hydroxymidazolam ethanolic extract of licorice g. glabra
NPDI-d_tXmg Licorice (Glycyrrhiza glabra) Cytochrome P450 inhibition by licorice species Glycyrrhiza glabra L. and fourteen licorice constituents Negligible inhibition of CYP2D6 by G. glabra Licorice extract In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2D6
dextromethorphan dextrorphan ethanolic extract of licorice g. glabra
NPDI-DtSHuA Licorice (Glycyrrhiza glabra) Cytochrome P450 inhibition by licorice species Glycyrrhiza glabra L. and fourteen licorice constituents Inhibition of CYP2C19 by G. glabra Licorice extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- ethanolic extract of licorice g. glabra