Glycyrrhetinic acid - CAR Activation Experiment - 1 CSV JSON

In Vitro Nuclear Receptor Induction Experiment

Glycyrrhetinic acid - CAR Activation Experiment - 1

Induction was detected.  Cutoff used —

Not available 

glycyrrhetinic acid

  • Pregnane X receptor (PXR)

Cell system PXR-transfected hepatic cells

Results

Using cell-based reporter assays, neither CAR nor GR can be activated by GA.

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

Cell-based CAR reporter assays of GA (10 µmol/L). TCPOBOP (250 nmol/L) was used as a positive control for CAR activation.

Luciferase activity (Reporter gene assay)