Inhibition of CYP2B6 by G. glabra Licorice extract CSV JSON

In Vitro Enzyme Inhibition Experiment

Inhibition of CYP2B6 by G. glabra Licorice extract

Inhibition was detected.  Cutoff used —

> 100 µg/mL

bupropion 750982

hydroxybupropion 4037950

  • CYP2B6 4308333

Cell fraction Pooled human liver microsomes -7999662

Results

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

cocktail assay, IC50 values were determined according to the method of Li et al. (2015).

Li, G., Huang, K., Nikolic, D., van Breemen, R.B., 2015. High-throughput cytochrome P450 cocktail inhibition assay for assessing drug-drug and drug-botanical interactions. Drug Metab. Dispos. 43, 1670–1678.

0.2 mg/mL

10 min

NADPH

12 µM

11 concentrations from 0.005–250 μg/mL