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ID Subject of Study Study Name Name Type Overall Effect Enzymes Transporters Object Object Metabolite Precipitant
NPDI-Rtoc6Q licoricidin Inhibition of CYP enzymes by licoricidin Inhibition of CYP2C8 by Licoricidin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C8
amodiaquine n-desethylamodiaquine licoricidin
NPDI-TGg2kA Licorice (Glycyrrhiza glabra) Cytochrome P450 inhibition by licorice species Glycyrrhiza glabra L. and fourteen licorice constituents Inhibition of CYP2C8 by G. glabra Licorice extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C8
amodiaquine n-desethylamodiaquine ethanolic extract of licorice g. glabra
NPDI-955SOw Licorice (Glycyrrhiza uralensis) Cytochrome P450 inhibition by licorice species Glycyrrhiza uralensis and fourteen licorice constituents Inhibition of CYP2C8 by G. uralensis Licorice extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C8
amodiaquine n-desethylamodiaquine ethanolic extract of licorice g. uralensis
NPDI-SUW3zQ Licorice (Glycyrrhiza inflata) Cytochrome P450 inhibition by licorice species Glycyrrhiza inflata and fourteen licorice constituents Inhibition of CYP2C8 by G. inflata Licorice extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C8
amodiaquine n-desethylamodiaquine ethanolic extract of licorice g. inflata
NPDI-Hh_vaQ Green Tea (Camellia sinensis) Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes Inhibition of CYP2C8 by (-)-Epigallocatechin Gallate in HLM (IC50 Determination) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C8
amodiaquine n-desethylamodiaquine (-)-epigallocatechin gallate
NPDI-rnQE5Q Green Tea (Camellia sinensis) Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes Inhibition of CYP2C8 by (-)-Epigallocatechin Gallate in HLM (Ki Determination) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C8
amodiaquine n-desethylamodiaquine (-)-epigallocatechin gallate
NPDI-XeGihA Kratom (Mitragyna speciosa) Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids Weak Inhibition of Paynantheine for CYP2C8 In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2C8
amodiaquine n-desethylamodiaquine paynantheine
NPDI-E0u5ug glycycoumarin Inhibition of CYP enzymes by glycycoumarin Inhibition of CYP2C8 by Glycycoumarin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C8
amodiaquine n-desethylamodiaquine glycycoumarin
NPDI-5_OSjg isoliquiritigenin Inhibition of CYP enzymes by isoliquiritigenin Inhibition of CYP2C8 by Isoliquiritigenin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C8
amodiaquine n-desethylamodiaquine isoliquiritigenin
NPDI-DJNbNQ licochalcone a Inhibition of CYP enzymes by licochalcone a Inhibition of CYP2C8 by Licochalcone A In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C8
amodiaquine n-desethylamodiaquine licochalcone a
NPDI-fleVog glycyrrhetinic acid Inhibition of CYP enzymes by glycyrrhetinic acid Inhibition of CYP2C8 by 18-beta-Glycyrrhetinic acid In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C8
amodiaquine n-desethylamodiaquine glycyrrhetinic acid
NPDI-o56vpA Kratom (Mitragyna speciosa) Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids Weak Inhibition of Corynantheidine for CYP2C8 In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2C8
amodiaquine n-desethylamodiaquine corynantheidine
NPDI-s8ImuA Kratom (Mitragyna speciosa) Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids Control Positive Inhibition for CYP2C8 In Vitro Enzyme Inhibition (Control experiment) positive — In Vitro Enzyme Inhibition
  • CYP2C8
amodiaquine n-desethylamodiaquine montelukast
NPDI-J2PdQQ Kratom (Mitragyna speciosa) Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids Inhibition of Mitragynine for CYP2C8 In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C8
amodiaquine n-desethylamodiaquine mitragynine
NPDI-JqmF7w Kratom (Mitragyna speciosa) Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids Inhibition of Speciociliatine for CYP2C8 In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C8
amodiaquine n-desethylamodiaquine speciociliatine
NPDI-U-ajPw Kratom (Mitragyna speciosa) Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids Weak Inhibition of 7-hydroxymitragynine for CYP2C8 In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2C8
amodiaquine n-desethylamodiaquine 7-hydroxymitragynine
NPDI-B_7tOA Kratom (Mitragyna speciosa) Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids Weak Inhibition of Speciogynine for CYP2C8 In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2C8
amodiaquine n-desethylamodiaquine speciogynine

Compound information from external resources

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