Weak Inhibition of 7-hydroxymitragynine for CYP2C8 CSV JSON

In Vitro Enzyme Inhibition Experiment

Weak Inhibition of 7-hydroxymitragynine for CYP2C8

Negligible Inhibition was detected.  Cutoff used —

IC50 = 45 μM

amodiaquine

7-hydroxymitragynine

n-desethylamodiaquine

  • CYP2C8 4306333

Cell fraction Pooled human liver microsomes -7999662

Results

% result estimated from Figure S4 at around 100 µM

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

0.1 mg/ml

200 µL

5 min

NADPH

7 µM

1 - 100 µM

Control Experiment