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  • Kratom (Mitragyna speciosa)

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ID Subject of Study Study Name Name Type Overall Effect Enzymes Transporters Object Object Metabolite Precipitant
NPDI-TjrSew Kratom (Mitragyna speciosa) Evaluation of In Vitro Absorption, Distribution, Metabolism, and Excretion (ADME) Properties of Mitragynine, 7-Hydroxymitragynine, and Mitraphylline 7-hyrdoxymitragynine P-gp Transport kinetics In Vitro Transporter Kinetics negative — No In Vitro Transport Activity
  • P-gp (ABCB1)
7-hydroxymitragynine
NPDI-iGAFkQ Kratom (Mitragyna speciosa) Evaluation of In Vitro Absorption, Distribution, Metabolism, and Excretion (ADME) Properties of Mitragynine, 7-Hydroxymitragynine, and Mitraphylline 7-Hydroxymitragynine p-gp transport kinetics MDCK In Vitro Transporter Kinetics negative — No In Vitro Transport Activity
  • P-gp (ABCB1)
7-hydroxymitragynine
NPDI-_5ld1Q Kratom (Mitragyna speciosa) Evaluation of In Vitro Absorption, Distribution, Metabolism, and Excretion (ADME) Properties of Mitragynine, 7-Hydroxymitragynine, and Mitraphylline 7-Hydroxymitragynine P-gp Inhibition In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • P-gp (ABCB1)
calcein-am 7-hydroxymitragynine
NPDI-4do0FA Kratom (Mitragyna speciosa) Effects of mitragynine and 7-hydroxymitragynine (the alkaloids of Mitragyna speciosa Korth) on 4-methylumbelliferone glucuronidation in rat and human liver microsomes and recombinant human uridine 5’- diphospho-glucuronosyltransferase isoforms Inhibition of UGT1A1 by 7-hydroxymitragynine In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT1A1
4-methylumbelliferone 4-methylumbelliferone glucuronide 7-hydroxymitragynine
NPDI-eMZPbA Kratom (Mitragyna speciosa) Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids Inhibition of 7-hydroxymitragynine for CYP2C19 In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- 7-hydroxymitragynine
NPDI-iASYyA Kratom (Mitragyna speciosa) Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids Weak Inhibition of 7-hydroxymitragynine for CYP3A4/5 In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP3A4
  • CYP3A5
testosterone 6beta-hydroxytestosterone 7-hydroxymitragynine
NPDI-olaGPQ Kratom (Mitragyna speciosa) Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids Weak Inhibition of 7-hydroxymitragynine for CYP3A4/5 In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP3A4
  • CYP3A5
midazolam 1'-hydroxymidazolam 7-hydroxymitragynine
NPDI-DLH-JQ Kratom (Mitragyna speciosa) Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids Weak Inhibition of 7-hydroxymitragynine for CYP2C9 In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2C9
diclofenac 4'-hydroxydiclofenac 7-hydroxymitragynine
NPDI-1vxnrQ Kratom (Mitragyna speciosa) Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids Weak Inhibition of 7-hydroxymitragynine for CYP1A2 In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP1A2
phenacetin acetaminophen 7-hydroxymitragynine
NPDI-cimaKA Kratom (Mitragyna speciosa) Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids Weak Inhibition of 7-hydroxymitragynine for CYP2D6 In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2D6
dextromethorphan dextrorphan 7-hydroxymitragynine
NPDI-U-ajPw Kratom (Mitragyna speciosa) Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids Weak Inhibition of 7-hydroxymitragynine for CYP2C8 In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2C8
amodiaquine n-desethylamodiaquine 7-hydroxymitragynine
NPDI-3C6gmg Kratom (Mitragyna speciosa) Effects of mitragynine and 7-hydroxymitragynine (the alkaloids of Mitragyna speciosa Korth) on 4-methylumbelliferone glucuronidation in rat and human liver microsomes and recombinant human uridine 5’- diphospho-glucuronosyltransferase isoforms Negligible inhibition of UGT2B7 by 7-hydroxymitragynine In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • UGT2B7
4-methylumbelliferone 4-methylumbelliferone glucuronide 7-hydroxymitragynine
NPDI-Q5Hs5A Kratom (Mitragyna speciosa) Effects of mitragynine and 7-hydroxymitragynine (the alkaloids of Mitragyna speciosa Korth) on 4-methylumbelliferone glucuronidation in rat and human liver microsomes and recombinant human uridine 5’- diphospho-glucuronosyltransferase isoforms No inhibition of UGT in human liver microsome activity by 7-hydroxymitragynine In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • UGT
4-methylumbelliferone 4-methylumbelliferone glucuronide 7-hydroxymitragynine
NPDI-38uQKg Kratom (Mitragyna speciosa) Metabolite profiling and identification of enzymes responsible for the metabolism of mitragynine, the major alkaloid of Mitragyna speciosa (kratom) Mitragynine metabolism and metabolite formation In Vitro Enzyme Screen positive — In Vitro Detectable Metabolism
  • CYP3A4
mitragynine 7-hydroxymitragynine
NPDI-XuAtuQ Kratom (Mitragyna speciosa) Characterization of Kratom material Characterization of Kratom material Characterization of Material

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