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ID Subject of Study Study Name Name Type Overall Effect Enzymes Transporters Object Object Metabolite Precipitant
NPDI-qMnZyA Kratom (Mitragyna speciosa) Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids Weak Inhibition of Corynantheidine for CYP3A4/5 In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP3A4
  • CYP3A5
testosterone 6beta-hydroxytestosterone corynantheidine
NPDI-P2Nw6g Kratom (Mitragyna speciosa) Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids Weak Inhibition of Speciogynine for CYP3A4/5 In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP3A4
  • CYP3A5
testosterone 6beta-hydroxytestosterone speciogynine
NPDI-iASYyA Kratom (Mitragyna speciosa) Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids Weak Inhibition of 7-hydroxymitragynine for CYP3A4/5 In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP3A4
  • CYP3A5
testosterone 6beta-hydroxytestosterone 7-hydroxymitragynine
NPDI-BLzT_g Kratom (Mitragyna speciosa) Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids Weak Inhibition of Mitragynine for CYP3A4/5 In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP3A4
  • CYP3A5
testosterone 6beta-hydroxytestosterone mitragynine
NPDI-aNb3lw Kratom (Mitragyna speciosa) Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids Weak Inhibition of Paynantheine for CYP3A4/5 In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP3A4
  • CYP3A5
testosterone 6beta-hydroxytestosterone paynantheine
NPDI-9xzv_Q Kratom (Mitragyna speciosa) Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids Control Positive Inhibition for CYP3A4/5 In Vitro Enzyme Inhibition (Control experiment) positive — In Vitro Enzyme Inhibition
  • CYP3A4
  • CYP3A5
testosterone 6beta-hydroxytestosterone ketoconazole
NPDI-2seH4Q Kratom (Mitragyna speciosa) Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids Weak Inhibition of Speciociliatine for CYP3A4/5 In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP3A4
  • CYP3A5
testosterone 6beta-hydroxytestosterone speciociliatine
NPDI-NUpDbg licochalcone a Inhibition of CYP enzymes by licochalcone a Inhibition of CYP3A4 by Licochalcone A In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
testosterone 6beta-hydroxytestosterone licochalcone a
NPDI-uw6NfQ isoliquiritigenin Inhibition of CYP enzymes by isoliquiritigenin Inhibition of CYP3A4 by Isoliquiritigenin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
testosterone 6beta-hydroxytestosterone isoliquiritigenin
NPDI-92ORyA glycyrrhetinic acid Inhibition of CYP enzymes by glycyrrhetinic acid Inhibition of CYP3A4 by 18-beta-Glycyrrhetinic acid In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
testosterone 6beta-hydroxytestosterone glycyrrhetinic acid
NPDI-wz4NXQ glabridin Inhibition of CYP enzymes by glabridin Inhibition of CYP3A4 by Glabridin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
testosterone 6beta-hydroxytestosterone glabridin
NPDI-beIHRg Licorice (Glycyrrhiza inflata) Cytochrome P450 inhibition by licorice species Glycyrrhiza inflata and fourteen licorice constituents Inhibition of CYP3A4 by G. inflata Licorice extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
testosterone 6beta-hydroxytestosterone ethanolic extract of licorice g. inflata
NPDI--eqgUQ Licorice (Glycyrrhiza uralensis) Cytochrome P450 inhibition by licorice species Glycyrrhiza uralensis and fourteen licorice constituents Negligible inhibition of CYP3A4 by G. uralensis Licorice extract In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP3A4
testosterone 6beta-hydroxytestosterone ethanolic extract of licorice g. uralensis
NPDI-DDS1fQ licoricidin Inhibition of CYP enzymes by licoricidin Inhibition of CYP3A4 by Licoricidin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
testosterone 6beta-hydroxytestosterone licoricidin
NPDI-itM3Yw Licorice (Glycyrrhiza glabra) Cytochrome P450 inhibition by licorice species Glycyrrhiza glabra L. and fourteen licorice constituents Inhibition of CYP3A4 by G. glabra Licorice extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
testosterone 6beta-hydroxytestosterone ethanolic extract of licorice g. glabra
NPDI-CDvKlQ Goldenseal (Hydrastis canadensis) Human Cytochrome P450 Inhibition and Metabolic-Intermediate Complex Formation By Goldenseal Extract and Its Methylenedioxyphenyl Components 3A4 Inhibition by (-) Hydrastine In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
testosterone 6beta-hydroxytestosterone (-)-beta-hydrastine
NPDI-39rhWg Goldenseal (Hydrastis canadensis) Human Cytochrome P450 Inhibition and Metabolic-Intermediate Complex Formation By Goldenseal Extract and Its Methylenedioxyphenyl Components 3A4 Inhibition by (+) Hydrastine In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
testosterone 6beta-hydroxytestosterone hydrastine
NPDI-_D6yiA Goldenseal (Hydrastis canadensis) Human Cytochrome P450 Inhibition and Metabolic-Intermediate Complex Formation By Goldenseal Extract and Its Methylenedioxyphenyl Components 3A4 Inhibition by Berberine In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
testosterone 6beta-hydroxytestosterone berberine
NPDI-OCQ06Q Goldenseal (Hydrastis canadensis) Human Cytochrome P450 Inhibition and Metabolic-Intermediate Complex Formation By Goldenseal Extract and Its Methylenedioxyphenyl Components 3A4 Inhibition by GS Extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
testosterone 6beta-hydroxytestosterone goldenseal root extract
NPDI-cYwbww Goldenseal (Hydrastis canadensis) An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents 3A4 Inhibition by Aq GS Extract (Testosterone) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
testosterone 6beta-hydroxytestosterone aqueous goldenseal extract
NPDI-ibIkjQ Goldenseal (Hydrastis canadensis) An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents 3A4 Inhibition by Ethanolic GS Extract (Testosterone) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
testosterone 6beta-hydroxytestosterone ethanolic goldenseal extract
NPDI-1ijwVg Goldenseal (Hydrastis canadensis) An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents 3A4 Inhibition by Berberine (Testosterone) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
testosterone 6beta-hydroxytestosterone berberine
NPDI-5wiIYg Goldenseal (Hydrastis canadensis) An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents 3A4 Inhibition by Hydrastine (Testosterone) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
testosterone 6beta-hydroxytestosterone hydrastine
NPDI-EjO7dA berberine Inhibitory Mechanisms of Human CYPs by Three Alkaloids Isolated from Traditional Chinese Herbs 1A2 preincubation with NADPH In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A2
testosterone 6beta-hydroxytestosterone berberine
NPDI-MsX4aw berberine Inhibitory Mechanisms of Human CYPs by Three Alkaloids Isolated from Traditional Chinese Herbs 1A2 preincubation without NADPH In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A2
testosterone 6beta-hydroxytestosterone berberine
NPDI-ykfGxQ berberine Inhibitory Mechanisms of Human CYPs by Three Alkaloids Isolated from Traditional Chinese Herbs 2D6 pre-incubation with NADPH In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
testosterone 6beta-hydroxytestosterone berberine
NPDI-wjO31A berberine Inhibitory Mechanisms of Human CYPs by Three Alkaloids Isolated from Traditional Chinese Herbs 2D6 preincubation without NADPH In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
testosterone 6beta-hydroxytestosterone berberine
NPDI-q61pww berberine Inhibitory Mechanisms of Human CYPs by Three Alkaloids Isolated from Traditional Chinese Herbs 3A4 preincubation with NADPH In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
testosterone 6beta-hydroxytestosterone berberine
NPDI-iBWK6Q berberine Inhibitory Mechanisms of Human CYPs by Three Alkaloids Isolated from Traditional Chinese Herbs 3A4 preincubation without NADPH In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
testosterone 6beta-hydroxytestosterone berberine

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