NPDI-DDS1fQ
|
licoricidin |
Inhibition of CYP enzymes by licoricidin
|
Inhibition of CYP3A4 by Licoricidin
|
In Vitro Enzyme Inhibition
|
positive
— In Vitro Enzyme Inhibition
|
|
|
testosterone
|
6beta-hydroxytestosterone
|
licoricidin
|
NPDI-itM3Yw
|
Licorice (Glycyrrhiza glabra) |
Cytochrome P450 inhibition by licorice species Glycyrrhiza glabra L. and fourteen licorice constituents
|
Inhibition of CYP3A4 by G. glabra Licorice extract
|
In Vitro Enzyme Inhibition
|
positive
— In Vitro Enzyme Inhibition
|
|
|
testosterone
|
6beta-hydroxytestosterone
|
ethanolic extract of licorice g. glabra
|
NPDI--eqgUQ
|
Licorice (Glycyrrhiza uralensis) |
Cytochrome P450 inhibition by licorice species Glycyrrhiza uralensis and fourteen licorice constituents
|
Negligible inhibition of CYP3A4 by G. uralensis Licorice extract
|
In Vitro Enzyme Inhibition
|
negative
— In Vitro Enzyme Negligible Inhibition
|
|
|
testosterone
|
6beta-hydroxytestosterone
|
ethanolic extract of licorice g. uralensis
|
NPDI-beIHRg
|
Licorice (Glycyrrhiza inflata) |
Cytochrome P450 inhibition by licorice species Glycyrrhiza inflata and fourteen licorice constituents
|
Inhibition of CYP3A4 by G. inflata Licorice extract
|
In Vitro Enzyme Inhibition
|
positive
— In Vitro Enzyme Inhibition
|
|
|
testosterone
|
6beta-hydroxytestosterone
|
ethanolic extract of licorice g. inflata
|
NPDI-q61pww
|
Goldenseal (Hydrastis canadensis) |
Inhibitory Mechanisms of Human CYPs by Three Alkaloids Isolated from Traditional Chinese Herbs
|
3A4 preincubation with NADPH
|
In Vitro Enzyme Inhibition
|
positive
— In Vitro Enzyme Inhibition
|
|
|
testosterone
|
6beta-hydroxytestosterone
|
berberine
|
NPDI-MsX4aw
|
Goldenseal (Hydrastis canadensis) |
Inhibitory Mechanisms of Human CYPs by Three Alkaloids Isolated from Traditional Chinese Herbs
|
1A2 preincubation without NADPH
|
In Vitro Enzyme Inhibition
|
positive
— In Vitro Enzyme Inhibition
|
|
|
testosterone
|
6beta-hydroxytestosterone
|
berberine
|
NPDI-wjO31A
|
Goldenseal (Hydrastis canadensis) |
Inhibitory Mechanisms of Human CYPs by Three Alkaloids Isolated from Traditional Chinese Herbs
|
2D6 preincubation without NADPH
|
In Vitro Enzyme Inhibition
|
positive
— In Vitro Enzyme Inhibition
|
|
|
testosterone
|
6beta-hydroxytestosterone
|
berberine
|
NPDI-ykfGxQ
|
Goldenseal (Hydrastis canadensis) |
Inhibitory Mechanisms of Human CYPs by Three Alkaloids Isolated from Traditional Chinese Herbs
|
2D6 pre-incubation with NADPH
|
In Vitro Enzyme Inhibition
|
positive
— In Vitro Enzyme Inhibition
|
|
|
testosterone
|
6beta-hydroxytestosterone
|
berberine
|
NPDI-iBWK6Q
|
Goldenseal (Hydrastis canadensis) |
Inhibitory Mechanisms of Human CYPs by Three Alkaloids Isolated from Traditional Chinese Herbs
|
3A4 preincubation without NADPH
|
In Vitro Enzyme Inhibition
|
positive
— In Vitro Enzyme Inhibition
|
|
|
testosterone
|
6beta-hydroxytestosterone
|
berberine
|
NPDI-EjO7dA
|
Goldenseal (Hydrastis canadensis) |
Inhibitory Mechanisms of Human CYPs by Three Alkaloids Isolated from Traditional Chinese Herbs
|
1A2 preincubation with NADPH
|
In Vitro Enzyme Inhibition
|
positive
— In Vitro Enzyme Inhibition
|
|
|
testosterone
|
6beta-hydroxytestosterone
|
berberine
|
NPDI-OCQ06Q
|
Goldenseal (Hydrastis canadensis) |
Human Cytochrome P450 Inhibition and Metabolic-Intermediate Complex Formation By Goldenseal Extract and Its Methylenedioxyphenyl Components
|
3A4 Inhibition by GS Extract
|
In Vitro Enzyme Inhibition
|
positive
— In Vitro Enzyme Inhibition
|
|
|
testosterone
|
6beta-hydroxytestosterone
|
goldenseal root extract
|
NPDI-5wiIYg
|
Goldenseal (Hydrastis canadensis) |
An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents
|
3A4 Inhibition by Hydrastine (Testosterone)
|
In Vitro Enzyme Inhibition
|
positive
— In Vitro Enzyme Inhibition
|
|
|
testosterone
|
6beta-hydroxytestosterone
|
hydrastine
|
NPDI-1ijwVg
|
Goldenseal (Hydrastis canadensis) |
An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents
|
3A4 Inhibition by Berberine (Testosterone)
|
In Vitro Enzyme Inhibition
|
positive
— In Vitro Enzyme Inhibition
|
|
|
testosterone
|
6beta-hydroxytestosterone
|
berberine
|
NPDI-ibIkjQ
|
Goldenseal (Hydrastis canadensis) |
An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents
|
3A4 Inhibition by Ethanolic GS Extract (Testosterone)
|
In Vitro Enzyme Inhibition
|
positive
— In Vitro Enzyme Inhibition
|
|
|
testosterone
|
6beta-hydroxytestosterone
|
ethanolic goldenseal extract
|
NPDI-cYwbww
|
Goldenseal (Hydrastis canadensis) |
An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents
|
3A4 Inhibition by Aq GS Extract (Testosterone)
|
In Vitro Enzyme Inhibition
|
positive
— In Vitro Enzyme Inhibition
|
|
|
testosterone
|
6beta-hydroxytestosterone
|
aqueous goldenseal extract
|
NPDI-_D6yiA
|
Goldenseal (Hydrastis canadensis) |
Human Cytochrome P450 Inhibition and Metabolic-Intermediate Complex Formation By Goldenseal Extract and Its Methylenedioxyphenyl Components
|
3A4 Inhibition by Berberine
|
In Vitro Enzyme Inhibition
|
positive
— In Vitro Enzyme Inhibition
|
|
|
testosterone
|
6beta-hydroxytestosterone
|
berberine
|
NPDI-39rhWg
|
Goldenseal (Hydrastis canadensis) |
Human Cytochrome P450 Inhibition and Metabolic-Intermediate Complex Formation By Goldenseal Extract and Its Methylenedioxyphenyl Components
|
3A4 Inhibition by (+) Hydrastine
|
In Vitro Enzyme Inhibition
|
positive
— In Vitro Enzyme Inhibition
|
|
|
testosterone
|
6beta-hydroxytestosterone
|
hydrastine
|
NPDI-CDvKlQ
|
Goldenseal (Hydrastis canadensis) |
Human Cytochrome P450 Inhibition and Metabolic-Intermediate Complex Formation By Goldenseal Extract and Its Methylenedioxyphenyl Components
|
3A4 Inhibition by (-) Hydrastine
|
In Vitro Enzyme Inhibition
|
positive
— In Vitro Enzyme Inhibition
|
|
|
testosterone
|
6beta-hydroxytestosterone
|
(-)-beta-hydrastine
|
NPDI-qMnZyA
|
Kratom (Mitragyna speciosa) |
Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids
|
Weak Inhibition of Corynantheidine for CYP3A4/5
|
In Vitro Enzyme Inhibition
|
negative
— In Vitro Enzyme Negligible Inhibition
|
|
|
testosterone
|
6beta-hydroxytestosterone
|
corynantheidine
|
NPDI-2seH4Q
|
Kratom (Mitragyna speciosa) |
Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids
|
Weak Inhibition of Speciociliatine for CYP3A4/5
|
In Vitro Enzyme Inhibition
|
negative
— In Vitro Enzyme Negligible Inhibition
|
|
|
testosterone
|
6beta-hydroxytestosterone
|
speciociliatine
|
NPDI-wz4NXQ
|
glabridin |
Inhibition of CYP enzymes by glabridin
|
Inhibition of CYP3A4 by Glabridin
|
In Vitro Enzyme Inhibition
|
positive
— In Vitro Enzyme Inhibition
|
|
|
testosterone
|
6beta-hydroxytestosterone
|
glabridin
|
NPDI-uw6NfQ
|
isoliquiritigenin |
Inhibition of CYP enzymes by isoliquiritigenin
|
Inhibition of CYP3A4 by Isoliquiritigenin
|
In Vitro Enzyme Inhibition
|
positive
— In Vitro Enzyme Inhibition
|
|
|
testosterone
|
6beta-hydroxytestosterone
|
isoliquiritigenin
|
NPDI-NUpDbg
|
licochalcone a |
Inhibition of CYP enzymes by licochalcone a
|
Inhibition of CYP3A4 by Licochalcone A
|
In Vitro Enzyme Inhibition
|
positive
— In Vitro Enzyme Inhibition
|
|
|
testosterone
|
6beta-hydroxytestosterone
|
licochalcone a
|
NPDI-aNb3lw
|
Kratom (Mitragyna speciosa) |
Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids
|
Weak Inhibition of Paynantheine for CYP3A4/5
|
In Vitro Enzyme Inhibition
|
negative
— In Vitro Enzyme Negligible Inhibition
|
|
|
testosterone
|
6beta-hydroxytestosterone
|
paynantheine
|
NPDI-iASYyA
|
Kratom (Mitragyna speciosa) |
Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids
|
Weak Inhibition of 7-hydroxymitragynine for CYP3A4/5
|
In Vitro Enzyme Inhibition
|
negative
— In Vitro Enzyme Negligible Inhibition
|
|
|
testosterone
|
6beta-hydroxytestosterone
|
7-hydroxymitragynine
|
NPDI-92ORyA
|
glycyrrhetinic acid |
Inhibition of CYP enzymes by glycyrrhetinic acid
|
Inhibition of CYP3A4 by 18-beta-Glycyrrhetinic acid
|
In Vitro Enzyme Inhibition
|
positive
— In Vitro Enzyme Inhibition
|
|
|
testosterone
|
6beta-hydroxytestosterone
|
glycyrrhetinic acid
|
NPDI-9xzv_Q
|
Kratom (Mitragyna speciosa) |
Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids
|
Control Positive Inhibition for CYP3A4/5
|
In Vitro Enzyme Inhibition
(Control experiment)
|
positive
— In Vitro Enzyme Inhibition
|
|
|
testosterone
|
6beta-hydroxytestosterone
|
ketoconazole
|
NPDI-BLzT_g
|
Kratom (Mitragyna speciosa) |
Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids
|
Weak Inhibition of Mitragynine for CYP3A4/5
|
In Vitro Enzyme Inhibition
|
negative
— In Vitro Enzyme Negligible Inhibition
|
|
|
testosterone
|
6beta-hydroxytestosterone
|
mitragynine
|
NPDI-P2Nw6g
|
Kratom (Mitragyna speciosa) |
Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids
|
Weak Inhibition of Speciogynine for CYP3A4/5
|
In Vitro Enzyme Inhibition
|
negative
— In Vitro Enzyme Negligible Inhibition
|
|
|
testosterone
|
6beta-hydroxytestosterone
|
speciogynine
|