11-hydroxy-delta-9-tetrahydrocannabinol
InChIKey: YCBKSSAWEUDACY-IAGOWNOFSA-N

11-OH-THC

Compound information managed by NaPDI


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ID Subject of Study Study Name Name Type Overall Effect Enzymes Transporters Object Object Metabolite Precipitant
NPDI-qk8qvw Cannabis (Cannabis sativa) Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids THC-OH-UGT1A9 In Vitro Enzyme Kinetics positive — In Vitro Detectable Kinetic Metabolism
  • UGT1A9
11-hydroxy-delta-9-tetrahydrocannabinol 11-nor-9-carboxy-delta9-tetrahydrocannabinol
NPDI-CWIhCg Cannabis (Cannabis sativa) Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids THC-OH-UGT1A10 In Vitro Enzyme Kinetics positive — In Vitro Detectable Kinetic Metabolism
  • UGT1A10
11-hydroxy-delta-9-tetrahydrocannabinol 11-nor-9-carboxy-delta9-tetrahydrocannabinol
NPDI-KKxwkg Cannabis (Cannabis sativa) Predicting the Potential for Cannabinoids to Precipitate Pharmacokinetic Drug Interactions via Reversible Inhibition or Inactivation of Major Cytochromes P450 11-OH-THC Inhibition of CYP1A2 In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A2
theophylline caffeine 11-hydroxy-delta-9-tetrahydrocannabinol
NPDI-KEwGCg Cannabis (Cannabis sativa) Predicting the Potential for Cannabinoids to Precipitate Pharmacokinetic Drug Interactions via Reversible Inhibition or Inactivation of Major Cytochromes P450 11-OH-THC Inhibition of CYP2C9 In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
diclofenac 4'-hydroxydiclofenac 11-hydroxy-delta-9-tetrahydrocannabinol
NPDI-kU7TmQ Cannabis (Cannabis sativa) Predicting the Potential for Cannabinoids to Precipitate Pharmacokinetic Drug Interactions via Reversible Inhibition or Inactivation of Major Cytochromes P450 11-OH-THC Inhibition on CYP2C19 In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
omeprazole 5-hydroxyomeprazole 11-hydroxy-delta-9-tetrahydrocannabinol
NPDI-7DFm1w Cannabis (Cannabis sativa) Predicting the Potential for Cannabinoids to Precipitate Pharmacokinetic Drug Interactions via Reversible Inhibition or Inactivation of Major Cytochromes P450 11-OH-THC Inhibition on CYP2D6 In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
dextromethorphan dextrorphan 11-hydroxy-delta-9-tetrahydrocannabinol
NPDI-fM7Sfg Cannabis (Cannabis sativa) Predicting the Potential for Cannabinoids to Precipitate Pharmacokinetic Drug Interactions via Reversible Inhibition or Inactivation of Major Cytochromes P450 11-OH-THC Inhibition on CYP3A In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A
testosterone 6beta-hydroxytestosterone 11-hydroxy-delta-9-tetrahydrocannabinol
NPDI-abEayg Cannabis (Cannabis sativa) Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes Weak Inhibition of 11-hydroxylation of delta-9-THC by ketoconazole In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP3A
delta-9-tetrahydrocannabinol 11-hydroxy-delta-9-tetrahydrocannabinol ketoconazole
NPDI-qmmKqA Cannabis (Cannabis sativa) Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes Inhibition of 11-hydroxylation of delta-9-THC by sulfaphenazole In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C
delta-9-tetrahydrocannabinol 11-hydroxy-delta-9-tetrahydrocannabinol sulfaphenazole
NPDI-IQtjvw Cannabis (Cannabis sativa) Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes Weak Inhibition of 11-hydroxylation of delta-9-THC by 7,8-benzoflavone In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP1A
delta-9-tetrahydrocannabinol 11-hydroxy-delta-9-tetrahydrocannabinol alpha-naphthoflavone

Compound information from external resources

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