delta-9-tetrahydrocannabinol
InChIKey: CYQFCXCEBYINGO-UHFFFAOYSA-N

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Compound information managed by NaPDI

  • Cannabis (Cannabis sativa)

None listed

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ID Subject of Study Study Name Name Type Overall Effect Enzymes Transporters Object Object Metabolite Precipitant
NPDI-rbqhsA Cannabis (Cannabis sativa) Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes Inhibition of 8-beta-hydroxylation of delta-9-THC by ketoconazole In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A
delta-9-tetrahydrocannabinol 8-beta-hydroxy-delta-9-tetrahydrocannabinol ketoconazole
NPDI-abEayg Cannabis (Cannabis sativa) Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes Weak Inhibition of 11-hydroxylation of delta-9-THC by ketoconazole In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP3A
delta-9-tetrahydrocannabinol 11-hydroxy-delta-9-tetrahydrocannabinol ketoconazole
NPDI-Yr3jng Cannabis (Cannabis sativa) Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes Weak Inhibition of 8-beta-hydroxylation of delta-9-THC by sulfaphenazole In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2C
delta-9-tetrahydrocannabinol 8-beta-hydroxy-delta-9-tetrahydrocannabinol sulfaphenazole
NPDI-qmmKqA Cannabis (Cannabis sativa) Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes Inhibition of 11-hydroxylation of delta-9-THC by sulfaphenazole In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C
delta-9-tetrahydrocannabinol 11-hydroxy-delta-9-tetrahydrocannabinol sulfaphenazole
NPDI-THVK4A Cannabis (Cannabis sativa) Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes No inhibition of 8-beta-hydroxylation of delta-9-THC by 7,8-benzoflavone In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP1A
delta-9-tetrahydrocannabinol 8-beta-hydroxy-delta-9-tetrahydrocannabinol alpha-naphthoflavone
NPDI-IQtjvw Cannabis (Cannabis sativa) Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes Weak Inhibition of 11-hydroxylation of delta-9-THC by 7,8-benzoflavone In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP1A
delta-9-tetrahydrocannabinol 11-hydroxy-delta-9-tetrahydrocannabinol alpha-naphthoflavone
NPDI-Rsay5Q Cannabis (Cannabis sativa) Interaction between naltrexone and oral THC in heavy marijuana smokers Effect of naltrexone on THC concentration In Vivo Interaction negative — No Effect (based on bioequivalence limits)
delta-9-tetrahydrocannabinol naltrexone
NPDI-a65Zxg Cannabis (Cannabis sativa) Interaction between Marihuana and Ethanol: Effects on Psychomotor Performance Mean THC Plasma Concentration with High Ethanol In Vivo Interaction negative — No Effect (based on bioequivalence limits)
delta-9-tetrahydrocannabinol ethanol
NPDI-R1QKZg Cannabis (Cannabis sativa) Pharmacological Effects of Cannabinoids on the Caco-2 Cell Culture Model of Intestinal Permeability THC In Vitro Transporter Kinetics positive — In Vitro Transport
  • P-gp (ABCB1)
 delta-9-tetrahydrocannabinol
NPDI-ypo3GA Cannabis (Cannabis sativa) Interaction between Marihuana and Ethanol: Effects on Psychomotor Performance Mean THC Plasma Concentration with High Ethanol In Vivo Interaction negative — No Effect (based on bioequivalence limits)
delta-9-tetrahydrocannabinol ethanol
NPDI-PwGUoQ Cannabis (Cannabis sativa) Interaction between Marihuana and Ethanol: Effects on Psychomotor Performance Mean THC Concentration with Placebo In Vivo Interaction negative — No Effect (based on bioequivalence limits)
delta-9-tetrahydrocannabinol placebo
NPDI-iJRQWg Cannabis (Cannabis sativa) Structural requirements for potent direct inhibition of human cytochrome P450 1A1 by cannabidiol: role of pentylresorcinol moiety. THC In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A1
7-ethoxyresorufin resorufin delta-9-tetrahydrocannabinol
NPDI-jZO6oQ Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. pHLM: THC-warfarin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
(s)-warfarin 7-hydroxywarfarin delta-9-tetrahydrocannabinol
NPDI-vUechg Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. iHLM: THC-warfarin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
(s)-warfarin 7-hydroxywarfarin delta-9-tetrahydrocannabinol
NPDI-59dZ4A Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. rCYP2C9: THC-warfarin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
(s)-warfarin 7-hydroxywarfarin delta-9-tetrahydrocannabinol
NPDI-Jb4JFA Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. iHLM: THC-diclofenac In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
diclofenac 4'-hydroxydiclofenac delta-9-tetrahydrocannabinol
NPDI-bM6NOQ Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. rCYP2C9: THC-diclofenac In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
diclofenac 4'-hydroxydiclofenac delta-9-tetrahydrocannabinol
NPDI-XBXjow Cannabis (Cannabis sativa) Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. Recombinant: THC-AMMC In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
3-[2-(n,n-diethyl-n-methylammonium)ethyl]-7-methoxy-4-methylcoumarin 3-[2-(n,n-diethyl-n-methylammonium)ethyl]-7-hydroxy-4-methylcoumarin delta-9-tetrahydrocannabinol
NPDI-Hsp-vg Cannabis (Cannabis sativa) Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. Recombinant: THC-dextramethorphan In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
dextromethorphan dextrorphan delta-9-tetrahydrocannabinol
NPDI-KQoVKg Cannabis (Cannabis sativa) Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. HLMs: THC-dextromethorphan In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
dextromethorphan dextrorphan delta-9-tetrahydrocannabinol
NPDI-8vislA Cannabis (Cannabis sativa) Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety. CYP3A4-THC In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP3A4
diltiazem n-demethyldiltiazem delta-9-tetrahydrocannabinol
NPDI-PS8_LQ Cannabis (Cannabis sativa) Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety. HLM-THC In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP3A
diltiazem n-demethyldiltiazem delta-9-tetrahydrocannabinol
NPDI-4tAywg Cannabis (Cannabis sativa) Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes 1A1: THC In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A1
7-ethoxyresorufin resorufin delta-9-tetrahydrocannabinol
NPDI-F-0XWg Cannabis (Cannabis sativa) Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes 1A2: THC In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A2
7-ethoxyresorufin resorufin delta-9-tetrahydrocannabinol
NPDI-DQGnJw Cannabis (Cannabis sativa) Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes HLMs: THC In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A1
7-ethoxyresorufin resorufin delta-9-tetrahydrocannabinol
NPDI-qHswZw Cannabis (Cannabis sativa) Cannabidiol induces expression of human cytochrome P450 1A1 that is possibly mediated through aryl hydrocarbon receptor signaling in HepG2 cells Induction of CYP1A1 mRNA expression by 50 µM delta-9-THC In Vitro Enzyme Induction positive — In Vitro Enzyme Induction
  • CYP1A1
delta-9-tetrahydrocannabinol
NPDI-t5Bygg Cannabis (Cannabis sativa) In Vitro Inhibition of Carboxylesterase 1 by Major Cannabinoids and Selected Metabolites Evaluation of Time-Dependent CES1 Inhibition by THC (0 min) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CES1
oseltamivir phosphate oseltamivir acid delta-9-tetrahydrocannabinol
NPDI-8d0Lug Cannabis (Cannabis sativa) In Vitro Inhibition of Carboxylesterase 1 by Major Cannabinoids and Selected Metabolites Evaluation of Time-Dependent CES1 Inhibition by THC (30 min) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CES1
oseltamivir phosphate oseltamivir acid delta-9-tetrahydrocannabinol
NPDI-AIeEmg Cannabis (Cannabis sativa) In Vitro Inhibition of Carboxylesterase 1 by Major Cannabinoids and Selected Metabolites Inhibition of CES1 by THC In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CES1
oseltamivir phosphate oseltamivir acid delta-9-tetrahydrocannabinol
NPDI-5GJkjQ Cannabis (Cannabis sativa) Predicting the Potential for Cannabinoids to Precipitate Pharmacokinetic Drug Interactions via Reversible Inhibition or Inactivation of Major Cytochromes P450 THC Inhibition of CYP1A2 In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A2
theophylline caffeine delta-9-tetrahydrocannabinol
NPDI-gvjqdw Cannabis (Cannabis sativa) Predicting the Potential for Cannabinoids to Precipitate Pharmacokinetic Drug Interactions via Reversible Inhibition or Inactivation of Major Cytochromes P450 THC Inhibition of CYP2C9 In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
diclofenac 4'-hydroxydiclofenac delta-9-tetrahydrocannabinol
NPDI-z-n9lA Cannabis (Cannabis sativa) Predicting the Potential for Cannabinoids to Precipitate Pharmacokinetic Drug Interactions via Reversible Inhibition or Inactivation of Major Cytochromes P450 THC Inhibition on CYP2C19 In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
omeprazole 5-hydroxyomeprazole delta-9-tetrahydrocannabinol
NPDI-MQ0Xtw Cannabis (Cannabis sativa) Predicting the Potential for Cannabinoids to Precipitate Pharmacokinetic Drug Interactions via Reversible Inhibition or Inactivation of Major Cytochromes P450 THC Inhibition on CYP2D6 In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
dextromethorphan dextrorphan delta-9-tetrahydrocannabinol
NPDI-Rm0CoQ Cannabis (Cannabis sativa) Predicting the Potential for Cannabinoids to Precipitate Pharmacokinetic Drug Interactions via Reversible Inhibition or Inactivation of Major Cytochromes P450 THC Inhibition on CYP3A In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A
testosterone 6beta-hydroxytestosterone delta-9-tetrahydrocannabinol
NPDI-NC4pjQ Cannabis (Cannabis sativa) The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells. CEM/VLB100: THC In Vitro Transporter Inhibition negative — In Vitro Transporter Non-inhibition
  • P-gp (ABCB1)
 rhodamine 123 delta-9-tetrahydrocannabinol
NPDI-zu7hCg Cannabis (Cannabis sativa) CB2 and TRPV1 receptors mediate cannabinoid actions on MDR1 expression in multidrug resistant cells THC In Vitro Transporter Induction positive — In Vitro Transporter Induction
  • P-gp (ABCB1)
 delta-9-tetrahydrocannabinol
NPDI-3LZeDA Cannabis (Cannabis sativa) The multidrug transporter ABCG2 (BCRP) is inhibited by plant-derived cannabinoids. Mitoxantrone-THC In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • BCRP (ABCG2)
 mitoxantrone delta-9-tetrahydrocannabinol
NPDI-J5A-Vg Cannabis (Cannabis sativa) The effects of cannabinoids on the pharmacokinetics of indinavir and nelfinavir NFV+THC PK at Baseline and Day 14 In Vivo Interaction negative — No Effect (based on bioequivalence limits)
nelfinavir delta-9-tetrahydrocannabinol
NPDI-noOe3w Cannabis (Cannabis sativa) Influence of cannabidiol on secobarbital effects and plasma kinetics Secobarbital Plasma Concentrations Following Sodium Secobarbital Ingestion and 150 µg/kg CBD Pretreatment In Vivo Interaction negative — No Effect (based on bioequivalence limits)
secobarbital delta-9-tetrahydrocannabinol
NPDI-S4_OQA Cannabis (Cannabis sativa) Interaction of drugs of abuse and maintenance treatments with human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2). Rh-123-THC In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • P-gp (ABCB1)
 rhodamine 123 delta-9-tetrahydrocannabinol
NPDI-qhVkgQ Cannabis (Cannabis sativa) The effects of cannabinoids on the pharmacokinetics of indinavir and nelfinavir IDV+THC PK at Baseline and Day 14 In Vivo Interaction negative — No Effect (based on bioequivalence limits)
indinavir delta-9-tetrahydrocannabinol
NPDI-8Ej-Bg Cannabis (Cannabis sativa) The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells. CCRF-CEM: THC In Vitro Transporter Inhibition negative — In Vitro Transporter Non-inhibition
  • P-gp (ABCB1)
 rhodamine 123 delta-9-tetrahydrocannabinol
NPDI-LCPweA Cannabis (Cannabis sativa) Interaction of drugs of abuse and maintenance treatments with human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2). Calcein-AM-THC In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • P-gp (ABCB1)
 calcein-am delta-9-tetrahydrocannabinol
NPDI-uUyadQ Cannabis (Cannabis sativa) Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1) Negligible inhibition of ABCC1 by THC In Vitro Transporter Inhibition negative — In Vitro Transporter Non-inhibition
  • ABCC1
 vincristine delta-9-tetrahydrocannabinol
NPDI-SCT2WA Cannabis (Cannabis sativa) Influence of cannabidiol on secobarbital effects and plasma kinetics Secobarbital Plasma Concentrations Following Sodium Secobarbital Ingestion and 500 µg/kg CBD Pretreatment In Vivo Interaction negative — No Effect (based on bioequivalence limits)
secobarbital delta-9-tetrahydrocannabinol
NPDI-lNsNoQ Cannabis (Cannabis sativa) Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1) Negligible inhibition of ABCC1 by THC In Vitro Transporter Inhibition negative — In Vitro Transporter Non-inhibition
  • ABCC1
 fluo3 delta-9-tetrahydrocannabinol
NPDI-tRoTQw Cannabis (Cannabis sativa) Cannabis extract (THC) Characterization of Material Characterization of Cannabis extract (THC) Characterization of Material
NPDI-soqMrQ Cannabis (Cannabis sativa) Cannabis Characterization of Bulk Plant Material Cannabis bulk plant Characterization of Material Characterization of Material
NPDI-uz4EAA Cannabis (Cannabis sativa) Cannabis extract (CBD) Characterization of Material Cannabis extract (Cannabidiol) Characterization of Material Characterization of Material
ID Subject of Study Name
NPDI-Rvn9SQ Cannabis (Cannabis sativa) Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes
NPDI-ZqVOgw Cannabis (Cannabis sativa) Interaction between naltrexone and oral THC in heavy marijuana smokers
NPDI-8lgFiA Cannabis (Cannabis sativa) Interaction between Marihuana and Ethanol: Effects on Psychomotor Performance
NPDI-BvR0Pw Cannabis (Cannabis sativa) Pharmacological Effects of Cannabinoids on the Caco-2 Cell Culture Model of Intestinal Permeability
NPDI-Ujn_7A Cannabis (Cannabis sativa) Structural requirements for potent direct inhibition of human cytochrome P450 1A1 by cannabidiol: role of pentylresorcinol moiety.
NPDI-vniY7Q Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity.
NPDI-ieYYdA Cannabis (Cannabis sativa) Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6.
NPDI-iHWMgQ Cannabis (Cannabis sativa) Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety.
NPDI-VYyv-A Cannabis (Cannabis sativa) Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes
NPDI-lY9NZQ Cannabis (Cannabis sativa) Cannabidiol induces expression of human cytochrome P450 1A1 that is possibly mediated through aryl hydrocarbon receptor signaling in HepG2 cells
NPDI-d4aGfw Cannabis (Cannabis sativa) In Vitro Inhibition of Carboxylesterase 1 by Major Cannabinoids and Selected Metabolites
NPDI-lalKkg Cannabis (Cannabis sativa) Predicting the Potential for Cannabinoids to Precipitate Pharmacokinetic Drug Interactions via Reversible Inhibition or Inactivation of Major Cytochromes P450
NPDI-cM9pfg Cannabis (Cannabis sativa) The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells.
NPDI-l0yevQ Cannabis (Cannabis sativa) CB2 and TRPV1 receptors mediate cannabinoid actions on MDR1 expression in multidrug resistant cells
NPDI-m-U3YQ Cannabis (Cannabis sativa) The multidrug transporter ABCG2 (BCRP) is inhibited by plant-derived cannabinoids.
NPDI-qOTUkQ Cannabis (Cannabis sativa) The effects of cannabinoids on the pharmacokinetics of indinavir and nelfinavir
NPDI-xYeUJQ Cannabis (Cannabis sativa) Influence of cannabidiol on secobarbital effects and plasma kinetics
NPDI-FhBdoQ Cannabis (Cannabis sativa) Interaction of drugs of abuse and maintenance treatments with human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2).
NPDI-ahQtSQ Cannabis (Cannabis sativa) Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1)
NPDI-2P3dUg Cannabis (Cannabis sativa) Cannabis extract (THC) Characterization of Material
NPDI-i4m0FA Cannabis (Cannabis sativa) Cannabis Characterization of Bulk Plant Material
NPDI-muoDdQ Cannabis (Cannabis sativa) Cannabis extract (CBD) Characterization of Material

Compound information from external resources

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