Need public description.

  • Cannabis (Cannabis sativa)

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ID Subject of Study Study Name Name Type Overall Effect Enzymes Transporters Object Object Metabolite Precipitant
NPDI-PwGUoQ Cannabis (Cannabis sativa) Interaction between Marihuana and Ethanol: Effects on Psychomotor Performance Mean THC Concentration with Placebo In Vivo Interaction negative — No Effect (based on bioequivalence limits)
delta-9-tetrahydrocannabinol (thc) placebo
NPDI-a65Zxg Cannabis (Cannabis sativa) Interaction between Marihuana and Ethanol: Effects on Psychomotor Performance Mean THC Plasma Concentration with High Ethanol In Vivo Interaction negative — No Effect (based on bioequivalence limits)
delta-9-tetrahydrocannabinol (thc) ethanol
NPDI-ypo3GA Cannabis (Cannabis sativa) Interaction between Marihuana and Ethanol: Effects on Psychomotor Performance Mean THC Plasma Concentration with High Ethanol In Vivo Interaction negative — No Effect (based on bioequivalence limits)
delta-9-tetrahydrocannabinol (thc) ethanol
NPDI-R1QKZg Cannabis (Cannabis sativa) Pharmacological Effects of Cannabinoids on the Caco-2 Cell Culture Model of Intestinal Permeability THC In Vitro Transporter Kinetics positive — In Vitro Transport
  • P-gp (ABCB1)
delta-9-tetrahydrocannabinol (thc)
NPDI-Rsay5Q Cannabis (Cannabis sativa) Interaction between naltrexone and oral THC in heavy marijuana smokers Effect of naltrexone on THC concentration In Vivo Interaction negative — No Effect (based on bioequivalence limits)
delta-9-tetrahydrocannabinol (thc) naltrexone
NPDI-4tAywg Cannabis (Cannabis sativa) Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes 1A1: THC In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A1
7-ethoxyresorufin resorufin delta-9-tetrahydrocannabinol (thc)
NPDI-F14zbg Cannabis (Cannabis sativa) Cannabidiol Is a Potent Inhibitor of the Catalytic Activity of Cytochrome P450 2C19 THC-omeprazole In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
omeprazole 5-hydroxyomeprazole delta-9-tetrahydrocannabinol (thc)
NPDI-iJRQWg Cannabis (Cannabis sativa) Structural requirements for potent direct inhibition of human cytochrome P450 1A1 by cannabidiol: role of pentylresorcinol moiety. THC In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A1
7-ethoxyresorufin resorufin delta-9-tetrahydrocannabinol (thc)
NPDI-_k7VAQ Cannabis (Cannabis sativa) Cannabidiol Is a Potent Inhibitor of the Catalytic Activity of Cytochrome P450 2C19 THC-OMF In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
3-o-methylfluorescein fluorescein delta-9-tetrahydrocannabinol (thc)
NPDI-noOe3w Cannabis (Cannabis sativa) Influence of cannabidiol on secobarbital effects and plasma kinetics Secobarbital Plasma Concentrations Following Sodium Secobarbital Ingestion and 150 µg/kg CBD Pretreatment In Vivo Interaction negative — No Effect (based on bioequivalence limits)
secobarbital delta-9-tetrahydrocannabinol (thc)
NPDI-SCT2WA Cannabis (Cannabis sativa) Influence of cannabidiol on secobarbital effects and plasma kinetics Secobarbital Plasma Concentrations Following Sodium Secobarbital Ingestion and 500 µg/kg CBD Pretreatment In Vivo Interaction negative — No Effect (based on bioequivalence limits)
secobarbital delta-9-tetrahydrocannabinol (thc)
NPDI-zu7hCg Cannabis (Cannabis sativa) CB2 and TRPV1 receptors mediate cannabinoid actions on MDR1 expression in multidrug resistant cells THC In Vitro Transporter Induction positive — In Vitro Transporter Induction
  • P-gp (ABCB1)
delta-9-tetrahydrocannabinol (thc)
NPDI-jZO6oQ Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. pHLM: THC-warfarin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
(s)-warfarin 7-hydroxywarfarin delta-9-tetrahydrocannabinol (thc)
NPDI-vUechg Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. iHLM: THC-warfarin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
(s)-warfarin 7-hydroxywarfarin delta-9-tetrahydrocannabinol (thc)
NPDI-Jb4JFA Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. iHLM: THC-diclofenac In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
diclofenac 4'-hydroxydiclofenac delta-9-tetrahydrocannabinol (thc)
NPDI-qhVkgQ Cannabis (Cannabis sativa) The effects of cannabinoids on the pharmacokinetics of indinavir and nelfinavir IDV+THC PK at Baseline and Day 14 In Vivo Interaction negative — No Effect (based on bioequivalence limits)
indinavir delta-9-tetrahydrocannabinol (thc)
NPDI-J5A-Vg Cannabis (Cannabis sativa) The effects of cannabinoids on the pharmacokinetics of indinavir and nelfinavir NFV+THC PK at Baseline and Day 14 In Vivo Interaction negative — No Effect (based on bioequivalence limits)
nelfinavir delta-9-tetrahydrocannabinol (thc)
NPDI-FGSLRQ Cannabis (Cannabis sativa) Cannabidiol Is a Potent Inhibitor of the Catalytic Activity of Cytochrome P450 2C19 THC-(S)-Mephenytoin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- delta-9-tetrahydrocannabinol (thc)
NPDI-59dZ4A Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. rCYP2C9: THC-warfarin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
(s)-warfarin 7-hydroxywarfarin delta-9-tetrahydrocannabinol (thc)
NPDI-bM6NOQ Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. rCYP2C9: THC-diclofenac In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
diclofenac 4'-hydroxydiclofenac delta-9-tetrahydrocannabinol (thc)
NPDI-XBXjow Cannabis (Cannabis sativa) Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. Recombinant: THC-AMMC In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
3-[2-(n,n-diethyl-n-methylammonium)ethyl]-7-methoxy-4-methylcoumarin 3-[2-(n,n-diethyl-n-methylammonium)ethyl]-7-hydroxy-4-methylcoumarin delta-9-tetrahydrocannabinol (thc)
NPDI-Hsp-vg Cannabis (Cannabis sativa) Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. Recombinant: THC-dextramethorphan In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
dextromethorphan dextrorphan delta-9-tetrahydrocannabinol (thc)
NPDI-KQoVKg Cannabis (Cannabis sativa) Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. HLMs: THC-dextromethorphan In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
dextromethorphan dextrorphan delta-9-tetrahydrocannabinol (thc)
NPDI-8vislA Cannabis (Cannabis sativa) Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety. CYP3A4-THC In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP3A4
diltiazem n-demethyldiltiazem delta-9-tetrahydrocannabinol (thc)
NPDI-PS8_LQ Cannabis (Cannabis sativa) Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety. HLM-THC In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP3A
diltiazem n-demethyldiltiazem delta-9-tetrahydrocannabinol (thc)
NPDI-LCPweA Cannabis (Cannabis sativa) Interaction of drugs of abuse and maintenance treatments with human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2). Calcein-AM-THC In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • P-gp (ABCB1)
calcein-am delta-9-tetrahydrocannabinol (thc)
NPDI-S4_OQA Cannabis (Cannabis sativa) Interaction of drugs of abuse and maintenance treatments with human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2). Rh-123-THC In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • P-gp (ABCB1)
rhodamine 123 delta-9-tetrahydrocannabinol (thc)
NPDI-3LZeDA Cannabis (Cannabis sativa) The multidrug transporter ABCG2 (BCRP) is inhibited by plant-derived cannabinoids. Mitoxantrone-THC In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • BCRP (ABCG2)
mitoxantrone delta-9-tetrahydrocannabinol (thc)
NPDI-F-0XWg Cannabis (Cannabis sativa) Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes 1A2: THC In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A2
7-ethoxyresorufin resorufin delta-9-tetrahydrocannabinol (thc)
NPDI-DQGnJw Cannabis (Cannabis sativa) Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes HLMs: THC In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A1
7-ethoxyresorufin resorufin delta-9-tetrahydrocannabinol (thc)
NPDI-8Ej-Bg Cannabis (Cannabis sativa) The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells. CCRF-CEM: THC In Vitro Transporter Inhibition negative — In Vitro Transporter Non-inhibition
  • P-gp (ABCB1)
rhodamine 123 delta-9-tetrahydrocannabinol (thc)
NPDI-NC4pjQ Cannabis (Cannabis sativa) The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells. CEM/VLB100: THC In Vitro Transporter Inhibition negative — In Vitro Transporter Non-inhibition
  • P-gp (ABCB1)
rhodamine 123 delta-9-tetrahydrocannabinol (thc)
NPDI-soqMrQ Cannabis (Cannabis sativa) Cannabis Characterization of Bulk Plant Material Cannabis bulk plant Characterization of Material Characterization of Material
ID Subject of Study Name
NPDI-8lgFiA Cannabis (Cannabis sativa) Interaction between Marihuana and Ethanol: Effects on Psychomotor Performance
NPDI-BvR0Pw Cannabis (Cannabis sativa) Pharmacological Effects of Cannabinoids on the Caco-2 Cell Culture Model of Intestinal Permeability
NPDI-ZqVOgw Cannabis (Cannabis sativa) Interaction between naltrexone and oral THC in heavy marijuana smokers
NPDI-VYyv-A Cannabis (Cannabis sativa) Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes
NPDI-CAApFQ Cannabis (Cannabis sativa) Cannabidiol Is a Potent Inhibitor of the Catalytic Activity of Cytochrome P450 2C19
NPDI-Ujn_7A Cannabis (Cannabis sativa) Structural requirements for potent direct inhibition of human cytochrome P450 1A1 by cannabidiol: role of pentylresorcinol moiety.
NPDI-xYeUJQ Cannabis (Cannabis sativa) Influence of cannabidiol on secobarbital effects and plasma kinetics
NPDI-l0yevQ Cannabis (Cannabis sativa) CB2 and TRPV1 receptors mediate cannabinoid actions on MDR1 expression in multidrug resistant cells
NPDI-vniY7Q Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity.
NPDI-qOTUkQ Cannabis (Cannabis sativa) The effects of cannabinoids on the pharmacokinetics of indinavir and nelfinavir
NPDI-ieYYdA Cannabis (Cannabis sativa) Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6.
NPDI-iHWMgQ Cannabis (Cannabis sativa) Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety.
NPDI-FhBdoQ Cannabis (Cannabis sativa) Interaction of drugs of abuse and maintenance treatments with human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2).
NPDI-m-U3YQ Cannabis (Cannabis sativa) The multidrug transporter ABCG2 (BCRP) is inhibited by plant-derived cannabinoids.
NPDI-cM9pfg Cannabis (Cannabis sativa) The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells.
NPDI-i4m0FA Cannabis (Cannabis sativa) Cannabis Characterization of Bulk Plant Material

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