|
NPDI-PwGUoQ
|
Cannabis (Cannabis sativa) |
Interaction between Marihuana and Ethanol: Effects on Psychomotor Performance
|
Mean THC Concentration with Placebo
|
In Vivo Interaction
|
negative
— No Effect (based on bioequivalence limits)
|
|
|
delta-9-tetrahydrocannabinol (thc)
|
|
placebo
|
|
NPDI-a65Zxg
|
Cannabis (Cannabis sativa) |
Interaction between Marihuana and Ethanol: Effects on Psychomotor Performance
|
Mean THC Plasma Concentration with High Ethanol
|
In Vivo Interaction
|
negative
— No Effect (based on bioequivalence limits)
|
|
|
delta-9-tetrahydrocannabinol (thc)
|
|
ethanol
|
|
NPDI-ypo3GA
|
Cannabis (Cannabis sativa) |
Interaction between Marihuana and Ethanol: Effects on Psychomotor Performance
|
Mean THC Plasma Concentration with High Ethanol
|
In Vivo Interaction
|
negative
— No Effect (based on bioequivalence limits)
|
|
|
delta-9-tetrahydrocannabinol (thc)
|
|
ethanol
|
|
NPDI-R1QKZg
|
Cannabis (Cannabis sativa) |
Pharmacological Effects of Cannabinoids on the Caco-2 Cell Culture Model of Intestinal Permeability
|
THC
|
In Vitro Transporter Kinetics
|
positive
— In Vitro Transport
|
|
|
delta-9-tetrahydrocannabinol (thc)
|
|
|
|
NPDI-Rsay5Q
|
Cannabis (Cannabis sativa) |
Interaction between naltrexone and oral THC in heavy marijuana smokers
|
Effect of naltrexone on THC concentration
|
In Vivo Interaction
|
negative
— No Effect (based on bioequivalence limits)
|
|
|
delta-9-tetrahydrocannabinol (thc)
|
|
naltrexone
|
|
NPDI-4tAywg
|
Cannabis (Cannabis sativa) |
Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes
|
1A1: THC
|
In Vitro Enzyme Inhibition
|
positive
— In Vitro Enzyme Inhibition
|
|
|
7-ethoxyresorufin
|
resorufin
|
delta-9-tetrahydrocannabinol (thc)
|
|
NPDI-F14zbg
|
Cannabis (Cannabis sativa) |
Cannabidiol Is a Potent Inhibitor of the Catalytic Activity of Cytochrome P450 2C19
|
THC-omeprazole
|
In Vitro Enzyme Inhibition
|
positive
— In Vitro Enzyme Inhibition
|
|
|
omeprazole
|
5-hydroxyomeprazole
|
delta-9-tetrahydrocannabinol (thc)
|
|
NPDI-iJRQWg
|
Cannabis (Cannabis sativa) |
Structural requirements for potent direct inhibition of human cytochrome P450 1A1 by cannabidiol: role of pentylresorcinol moiety.
|
THC
|
In Vitro Enzyme Inhibition
|
positive
— In Vitro Enzyme Inhibition
|
|
|
7-ethoxyresorufin
|
resorufin
|
delta-9-tetrahydrocannabinol (thc)
|
|
NPDI-_k7VAQ
|
Cannabis (Cannabis sativa) |
Cannabidiol Is a Potent Inhibitor of the Catalytic Activity of Cytochrome P450 2C19
|
THC-OMF
|
In Vitro Enzyme Inhibition
|
positive
— In Vitro Enzyme Inhibition
|
|
|
3-o-methylfluorescein
|
fluorescein
|
delta-9-tetrahydrocannabinol (thc)
|
|
NPDI-noOe3w
|
Cannabis (Cannabis sativa) |
Influence of cannabidiol on secobarbital effects and plasma kinetics
|
Secobarbital Plasma Concentrations Following Sodium Secobarbital Ingestion and 150 µg/kg CBD Pretreatment
|
In Vivo Interaction
|
negative
— No Effect (based on bioequivalence limits)
|
|
|
secobarbital
|
|
delta-9-tetrahydrocannabinol (thc)
|
|
NPDI-SCT2WA
|
Cannabis (Cannabis sativa) |
Influence of cannabidiol on secobarbital effects and plasma kinetics
|
Secobarbital Plasma Concentrations Following Sodium Secobarbital Ingestion and 500 µg/kg CBD Pretreatment
|
In Vivo Interaction
|
negative
— No Effect (based on bioequivalence limits)
|
|
|
secobarbital
|
|
delta-9-tetrahydrocannabinol (thc)
|
|
NPDI-zu7hCg
|
Cannabis (Cannabis sativa) |
CB2 and TRPV1 receptors mediate cannabinoid actions on MDR1 expression in multidrug resistant cells
|
THC
|
In Vitro Transporter Induction
|
positive
— In Vitro Transporter Induction
|
|
|
|
|
delta-9-tetrahydrocannabinol (thc)
|
|
NPDI-jZO6oQ
|
Cannabis (Cannabis sativa) |
Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity.
|
pHLM: THC-warfarin
|
In Vitro Enzyme Inhibition
|
positive
— In Vitro Enzyme Inhibition
|
|
|
(s)-warfarin
|
7-hydroxywarfarin
|
delta-9-tetrahydrocannabinol (thc)
|
|
NPDI-vUechg
|
Cannabis (Cannabis sativa) |
Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity.
|
iHLM: THC-warfarin
|
In Vitro Enzyme Inhibition
|
positive
— In Vitro Enzyme Inhibition
|
|
|
(s)-warfarin
|
7-hydroxywarfarin
|
delta-9-tetrahydrocannabinol (thc)
|
|
NPDI-Jb4JFA
|
Cannabis (Cannabis sativa) |
Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity.
|
iHLM: THC-diclofenac
|
In Vitro Enzyme Inhibition
|
positive
— In Vitro Enzyme Inhibition
|
|
|
diclofenac
|
4'-hydroxydiclofenac
|
delta-9-tetrahydrocannabinol (thc)
|
|
NPDI-qhVkgQ
|
Cannabis (Cannabis sativa) |
The effects of cannabinoids on the pharmacokinetics of indinavir and nelfinavir
|
IDV+THC PK at Baseline and Day 14
|
In Vivo Interaction
|
negative
— No Effect (based on bioequivalence limits)
|
|
|
indinavir
|
|
delta-9-tetrahydrocannabinol (thc)
|
|
NPDI-J5A-Vg
|
Cannabis (Cannabis sativa) |
The effects of cannabinoids on the pharmacokinetics of indinavir and nelfinavir
|
NFV+THC PK at Baseline and Day 14
|
In Vivo Interaction
|
negative
— No Effect (based on bioequivalence limits)
|
|
|
nelfinavir
|
|
delta-9-tetrahydrocannabinol (thc)
|
|
NPDI-FGSLRQ
|
Cannabis (Cannabis sativa) |
Cannabidiol Is a Potent Inhibitor of the Catalytic Activity of Cytochrome P450 2C19
|
THC-(S)-Mephenytoin
|
In Vitro Enzyme Inhibition
|
positive
— In Vitro Enzyme Inhibition
|
|
|
mephenytoin, (s)-
|
4-hydroxymephenytoin, (s)-
|
delta-9-tetrahydrocannabinol (thc)
|
|
NPDI-59dZ4A
|
Cannabis (Cannabis sativa) |
Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity.
|
rCYP2C9: THC-warfarin
|
In Vitro Enzyme Inhibition
|
positive
— In Vitro Enzyme Inhibition
|
|
|
(s)-warfarin
|
7-hydroxywarfarin
|
delta-9-tetrahydrocannabinol (thc)
|
|
NPDI-bM6NOQ
|
Cannabis (Cannabis sativa) |
Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity.
|
rCYP2C9: THC-diclofenac
|
In Vitro Enzyme Inhibition
|
positive
— In Vitro Enzyme Inhibition
|
|
|
diclofenac
|
4'-hydroxydiclofenac
|
delta-9-tetrahydrocannabinol (thc)
|
|
NPDI-XBXjow
|
Cannabis (Cannabis sativa) |
Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6.
|
Recombinant: THC-AMMC
|
In Vitro Enzyme Inhibition
|
positive
— In Vitro Enzyme Inhibition
|
|
|
3-[2-(n,n-diethyl-n-methylammonium)ethyl]-7-methoxy-4-methylcoumarin
|
3-[2-(n,n-diethyl-n-methylammonium)ethyl]-7-hydroxy-4-methylcoumarin
|
delta-9-tetrahydrocannabinol (thc)
|
|
NPDI-Hsp-vg
|
Cannabis (Cannabis sativa) |
Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6.
|
Recombinant: THC-dextramethorphan
|
In Vitro Enzyme Inhibition
|
positive
— In Vitro Enzyme Inhibition
|
|
|
dextromethorphan
|
dextrorphan
|
delta-9-tetrahydrocannabinol (thc)
|
|
NPDI-KQoVKg
|
Cannabis (Cannabis sativa) |
Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6.
|
HLMs: THC-dextromethorphan
|
In Vitro Enzyme Inhibition
|
positive
— In Vitro Enzyme Inhibition
|
|
|
dextromethorphan
|
dextrorphan
|
delta-9-tetrahydrocannabinol (thc)
|
|
NPDI-8vislA
|
Cannabis (Cannabis sativa) |
Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety.
|
CYP3A4-THC
|
In Vitro Enzyme Inhibition
|
negative
— In Vitro Enzyme Negligible Inhibition
|
|
|
diltiazem
|
n-demethyldiltiazem
|
delta-9-tetrahydrocannabinol (thc)
|
|
NPDI-PS8_LQ
|
Cannabis (Cannabis sativa) |
Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety.
|
HLM-THC
|
In Vitro Enzyme Inhibition
|
negative
— In Vitro Enzyme Negligible Inhibition
|
|
|
diltiazem
|
n-demethyldiltiazem
|
delta-9-tetrahydrocannabinol (thc)
|
|
NPDI-LCPweA
|
Cannabis (Cannabis sativa) |
Interaction of drugs of abuse and maintenance treatments with human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2).
|
Calcein-AM-THC
|
In Vitro Transporter Inhibition
|
positive
— In Vitro Transporter Inhibition
|
|
|
calcein-am
|
|
delta-9-tetrahydrocannabinol (thc)
|
|
NPDI-S4_OQA
|
Cannabis (Cannabis sativa) |
Interaction of drugs of abuse and maintenance treatments with human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2).
|
Rh-123-THC
|
In Vitro Transporter Inhibition
|
positive
— In Vitro Transporter Inhibition
|
|
|
rhodamine 123
|
|
delta-9-tetrahydrocannabinol (thc)
|
|
NPDI-3LZeDA
|
Cannabis (Cannabis sativa) |
The multidrug transporter ABCG2 (BCRP) is inhibited by plant-derived cannabinoids.
|
Mitoxantrone-THC
|
In Vitro Transporter Inhibition
|
positive
— In Vitro Transporter Inhibition
|
|
|
mitoxantrone
|
|
delta-9-tetrahydrocannabinol (thc)
|
|
NPDI-F-0XWg
|
Cannabis (Cannabis sativa) |
Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes
|
1A2: THC
|
In Vitro Enzyme Inhibition
|
positive
— In Vitro Enzyme Inhibition
|
|
|
7-ethoxyresorufin
|
resorufin
|
delta-9-tetrahydrocannabinol (thc)
|
|
NPDI-DQGnJw
|
Cannabis (Cannabis sativa) |
Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes
|
HLMs: THC
|
In Vitro Enzyme Inhibition
|
positive
— In Vitro Enzyme Inhibition
|
|
|
7-ethoxyresorufin
|
resorufin
|
delta-9-tetrahydrocannabinol (thc)
|
|
NPDI-8Ej-Bg
|
Cannabis (Cannabis sativa) |
The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells.
|
CCRF-CEM: THC
|
In Vitro Transporter Inhibition
|
negative
— In Vitro Transporter Non-inhibition
|
|
|
rhodamine 123
|
|
delta-9-tetrahydrocannabinol (thc)
|
|
NPDI-NC4pjQ
|
Cannabis (Cannabis sativa) |
The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells.
|
CEM/VLB100: THC
|
In Vitro Transporter Inhibition
|
negative
— In Vitro Transporter Non-inhibition
|
|
|
rhodamine 123
|
|
delta-9-tetrahydrocannabinol (thc)
|
|
NPDI-soqMrQ
|
Cannabis (Cannabis sativa) |
Cannabis Characterization of Bulk Plant Material
|
Cannabis bulk plant Characterization of Material
|
Characterization of Material
|
|
|
|
|
|
|
