In Vitro Enzyme Inhibition Experiment

THC Inhibition of CYP2C9

Inhibition was detected.  Cutoff used —

Table 1 lists the oral and inhalational doses and estimated maximum plasma concentrations of CBD, THC, and THC metabolites used for predicting the magnitude of pharmacokinetic cannabinoid-drug interactions. 

diclofenac 1124300

delta-9-tetrahydrocannabinol

4'-hydroxydiclofenac

  • CYP2C9 4309227

Cell fraction Pooled human liver microsomes -7999662

Results

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

0.5 mg/ml

Commercially available

5 µM