- Natural product: Cannabis (Cannabis sativa)
- Associated study: Interaction between Marihuana and Ethanol: Effects on Psychomotor Performance
In Vivo Interaction Study
Mean THC Concentration with Placebo
No Effect (based on bioequivalence limits) was detected.
Figure 2
Placebo is orange juice sprayed with 100-proof vodka
Results
Values converted from minutes.
Original values:
- Time to peak (min): 7.2 ± 0.7
- AUC0-315 (ng*min/mL): 3695 ± 597
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
Placebo-controlled
Randomized crossover
Single dosing
Males
6
Limited information is available
0, 30, 45, 60, 75, 90, 120, 150, 180, 210, 240, 360 min
Drug or Natural Product Administration
Inhalation
Cigarette
2.4% THC
Once
Determined by subject
Oral
Liquid
300 mL
50 mL doses Q 5min
30 min
Not specified
Pharmacodynamics (PD) & Adverse Events
Subjective Ratings of Intoxication Utilized a 0-100 scale with use of previous ratings to use for comparison.
Physiological Effects Continuous ECG to measure heart rate measured from 60 min before drug administration and for ensuing three hours.
Performance Effects Utilized Simulator Evaluation of Drug Impairment instrument with added foor response. Tasked to press a button or foot pedal depending on what value was displayed on a monitor.
Further information is listed under the Materials and Methods section in the text.
Cardiac disorders
35200000
Psychiatric disorders
36900000
Subjective Ratings of Intoxication "Volunteers were able to consistently differentiate and rate the effects of ethanol from those of marihuana. [...] The mean subjective ratings of marihuana “high” ap- peared to be increased by the prior ingestion of ethanol in a dose-dependent fashion (Fig. 4). However, these in- creases were not statistically significant."
Physiological Effects "The results indicate that the administration of placebo ethanol or the two doses of ethanol in combination with the smoking of placebo marihuana induced a modest deceleration of the heart rate over the period of observation. [...] The smoking of THC-containing marihuana markedly accelerated the heart rate."
Performance Effects "The accuracy of the responses across task components on the SEDI task varied significantly."
More information can be found under the Results section of the text.