In Vitro Enzyme Inhibition Experiment

CYP3A4-THC

Negligible Inhibition was detected.  Cutoff used — Not specified

diltiazem

delta-9-tetrahydrocannabinol

n-demethyldiltiazem

  • CYP3A4 4306811

Recombinant expression system Baculovirus-insect cells
Cytochrome B5 Co-expressed

Results

Table 2

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

2 pmol

Commercially available

200 μL

15 min

MgCl2
NADPH regenerating system

50 μM

NADPH with precipitant

0-50 μM