In Vitro Enzyme Inhibition Experiment

pHLM: THC-warfarin

Inhibition was detected.  Cutoff used — Not specified

(s)-warfarin

7-hydroxywarfarin

  • CYP2C9 4309227

Cell fraction Pooled human liver microsomes -7999662

Results

Tables 2, 3, and 4.
IC50 pre-incubation recorded at 20 min

Sample Compound measured Measurement Value Study sequence Additional information N replicates

Experimental Conditions

20 μg

Commercially available

200 μL

20 min

MgCl2
NADPH regenerating system

5 min

NADPH with precipitant