In Vitro Enzyme Inhibition Experiment

THC Inhibition of CYP1A2

Inhibition was detected.  Cutoff used —

Table 1 lists the oral and inhalational doses and estimated maximum plasma concentrations of CBD, THC, and THC metabolites used for predicting the magnitude of pharmacokinetic cannabinoid-drug interactions. 

theophylline 1237049

delta-9-tetrahydrocannabinol

caffeine 1134439

  • CYP1A2 4312402

Cell fraction Pooled human liver microsomes -7999662

Results

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

0.1 mg/ml

Commercially available

50 µM