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  • Cannabis (Cannabis sativa)

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ID Subject of Study Study Name Name Type Overall Effect Enzymes Transporters Object Object Metabolite Precipitant
NPDI-PxRYvA Cannabis (Cannabis sativa) Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids CBN-UGT1A10 In Vitro Enzyme Kinetics positive — In Vitro Detectable Kinetic Metabolism
  • UGT1A10
cannabinol 11-hydroxycannabinol
NPDI-Qoqt5Q Cannabis (Cannabis sativa) Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids CBN-UGT1A7 In Vitro Enzyme Kinetics positive — In Vitro Detectable Kinetic Metabolism
  • UGT1A7
cannabinol 11-hydroxycannabinol
NPDI-ToTRjw Cannabis (Cannabis sativa) Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids CBN-UGT1A8 In Vitro Enzyme Kinetics positive — In Vitro Detectable Kinetic Metabolism
  • UGT1A8
cannabinol 11-hydroxycannabinol
NPDI-akOrWg Cannabis (Cannabis sativa) Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids CBN-UGT1A9 In Vitro Enzyme Kinetics positive — In Vitro Detectable Kinetic Metabolism
  • UGT1A9
cannabinol 11-hydroxycannabinol
NPDI-I4dv_g Cannabis (Cannabis sativa) Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes Inhibition of 8-hydroxylation of cannabinol by ketoconazole In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A
cannabinol 8-hydroxycannabinol ketoconazole
NPDI-VpD-Xg Cannabis (Cannabis sativa) Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes Weak Inhibition of 11-hydroxylation of cannabinol by ketoconazole In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP3A
cannabinol 11-hydroxycannabinol ketoconazole
NPDI-uxfWFg Cannabis (Cannabis sativa) Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes Weak Inhibition of 8-hydroxylation of cannabinol by sulfaphenazole In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2C
cannabinol 8-hydroxycannabinol sulfaphenazole
NPDI-8flCOQ Cannabis (Cannabis sativa) Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes Inhibition of 11-hydroxylation of cannabinol by sulfaphenazole In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C
cannabinol 11-hydroxycannabinol sulfaphenazole
NPDI-YQ1c2Q Cannabis (Cannabis sativa) Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes Weak Inhibition of 11-hydroxylation of cannabinol by 7,8-benzoflavone In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP1A
cannabinol 11-hydroxycannabinol alpha-naphthoflavone
NPDI-v8ghug Cannabis (Cannabis sativa) Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes No Inhibition of 8-hydroxylation of cannabinol by 7,8-benzoflavone In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP1A
cannabinol 8-hydroxycannabinol alpha-naphthoflavone
NPDI-7RWWrg Cannabis (Cannabis sativa) Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1) Inhibition of ABCC1 by Cannabinol In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • ABCC1
vincristine cannabinol
NPDI-ZNPhvw Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. iHLM: CBN-warfarin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
(s)-warfarin 7-hydroxywarfarin cannabinol
NPDI-jwN2Vw Cannabis (Cannabis sativa) Involvement of UDP-Glucuronosyltransferases UGT1A9 and UGT2B7 in Ethanol Glucuronidation, and Interactions with Common Drugs of Abuse CBN-UGT1A9 Inhibition In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT1A9
ethanol ethyl glucuronide cannabinol
NPDI-0g58zw Cannabis (Cannabis sativa) Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. Recombinant: CBN-dextromethorphan In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
dextromethorphan dextrorphan cannabinol
NPDI-p2jqFw Cannabis (Cannabis sativa) Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. pHLM: CBN-dextromethorphan In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
dextromethorphan dextrorphan cannabinol
NPDI-7hkXUg Cannabis (Cannabis sativa) Involvement of UDP-Glucuronosyltransferases UGT1A9 and UGT2B7 in Ethanol Glucuronidation, and Interactions with Common Drugs of Abuse CBN on ethanol glucuronidation In Vitro Enzyme Induction positive — In Vitro Enzyme Induction
  • UGT
cannabinol
NPDI-JvqWDQ Cannabis (Cannabis sativa) Involvement of UDP-Glucuronosyltransferases UGT1A9 and UGT2B7 in Ethanol Glucuronidation, and Interactions with Common Drugs of Abuse CBN-UGT2B7 Induction In Vitro Enzyme Induction positive — In Vitro Enzyme Induction
  • UGT2B7
cannabinol
NPDI-mGu2ew Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. pHLM: CBN-warfarin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
(s)-warfarin 7-hydroxywarfarin cannabinol
NPDI-wt2yDg Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. rCYP2C9: CBN-warfarin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
(s)-warfarin 7-hydroxywarfarin cannabinol
NPDI-V1SemA Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. iHLM: CBN-diclofenac In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
diclofenac 4'-hydroxydiclofenac cannabinol
NPDI-KqafWg Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. rCYP2C9: CBN-diclofenac In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
diclofenac 4'-hydroxydiclofenac cannabinol
NPDI-b-kubA Cannabis (Cannabis sativa) Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. Recombinant: CBN-AMMC In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
3-[2-(n,n-diethyl-n-methylammonium)ethyl]-7-methoxy-4-methylcoumarin 3-[2-(n,n-diethyl-n-methylammonium)ethyl]-7-hydroxy-4-methylcoumarin cannabinol
NPDI-ens_Gw Cannabis (Cannabis sativa) Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety. CYP3A4-CBN In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP3A4
diltiazem n-demethyldiltiazem cannabinol
NPDI-yszOMw Cannabis (Cannabis sativa) Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety. HLM-CBN In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP3A
diltiazem n-demethyldiltiazem cannabinol
NPDI-dsHL7w Cannabis (Cannabis sativa) The multidrug transporter ABCG2 (BCRP) is inhibited by plant-derived cannabinoids. Mitoxantrone-CBN In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • BCRP (ABCG2)
mitoxantrone cannabinol
NPDI-v65nxg Cannabis (Cannabis sativa) Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes 1A1: CBN In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A1
7-ethoxyresorufin resorufin cannabinol
NPDI-RC8Kxw Cannabis (Cannabis sativa) Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes 1A2: CBN In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A2
7-ethoxyresorufin resorufin cannabinol
NPDI-XKoD2A Cannabis (Cannabis sativa) Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes HLMs: CBN In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A1
7-ethoxyresorufin resorufin cannabinol
NPDI-G8_czw Cannabis (Cannabis sativa) The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells. CEM/VLB100: CBN In Vitro Transporter Inhibition negative — In Vitro Transporter Non-inhibition
  • P-gp (ABCB1)
rhodamine 123 cannabinol
NPDI-EqzxjQ Cannabis (Cannabis sativa) The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells. CCRF-CEM: CBN In Vitro Transporter Inhibition negative — In Vitro Transporter Non-inhibition
  • P-gp (ABCB1)
rhodamine 123 cannabinol
NPDI-LI0O-A Cannabis (Cannabis sativa) In Vitro Inhibition of Carboxylesterase 1 by Major Cannabinoids and Selected Metabolites Inhibition of CES1 by CBN In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CES1
oseltamivir phosphate oseltamivir acid cannabinol
NPDI--0E9EQ Cannabis (Cannabis sativa) In Vitro Inhibition of Carboxylesterase 1 by Major Cannabinoids and Selected Metabolites Evaluation of Time-Dependent CES1 Inhibition by CBN (30 min) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CES1
oseltamivir phosphate oseltamivir acid cannabinol
NPDI-jW07Iw Cannabis (Cannabis sativa) Cannabidiol induces expression of human cytochrome P450 1A1 that is possibly mediated through aryl hydrocarbon receptor signaling in HepG2 cells Non-induction of CYP1A1 mRNA expression by 50 ┬ÁM cannabinol In Vitro Enzyme Induction negative — In Vitro Enzyme Non-induction
  • CYP1A1
cannabinol
NPDI-2KocMg Cannabis (Cannabis sativa) In Vitro Inhibition of Carboxylesterase 1 by Major Cannabinoids and Selected Metabolites Evaluation of Time-Dependent CES1 Inhibition by CBN (0 min) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CES1
oseltamivir phosphate oseltamivir acid cannabinol
NPDI-JnMHww Cannabis (Cannabis sativa) Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1) Negligible inhibition of ABCC1 by Cannabinol In Vitro Transporter Inhibition negative — In Vitro Transporter Non-inhibition
  • ABCC1
fluo3 cannabinol
NPDI-soqMrQ Cannabis (Cannabis sativa) Cannabis Characterization of Bulk Plant Material Cannabis bulk plant Characterization of Material Characterization of Material
ID Subject of Study Name
NPDI-sUzV-g Cannabis (Cannabis sativa) Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids
NPDI-Rvn9SQ Cannabis (Cannabis sativa) Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes
NPDI-ahQtSQ Cannabis (Cannabis sativa) Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1)
NPDI-vniY7Q Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity.
NPDI-vhBMSw Cannabis (Cannabis sativa) Involvement of UDP-Glucuronosyltransferases UGT1A9 and UGT2B7 in Ethanol Glucuronidation, and Interactions with Common Drugs of Abuse
NPDI-ieYYdA Cannabis (Cannabis sativa) Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6.
NPDI-iHWMgQ Cannabis (Cannabis sativa) Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety.
NPDI-m-U3YQ Cannabis (Cannabis sativa) The multidrug transporter ABCG2 (BCRP) is inhibited by plant-derived cannabinoids.
NPDI-VYyv-A Cannabis (Cannabis sativa) Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes
NPDI-cM9pfg Cannabis (Cannabis sativa) The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells.
NPDI-d4aGfw Cannabis (Cannabis sativa) In Vitro Inhibition of Carboxylesterase 1 by Major Cannabinoids and Selected Metabolites
NPDI-lY9NZQ Cannabis (Cannabis sativa) Cannabidiol induces expression of human cytochrome P450 1A1 that is possibly mediated through aryl hydrocarbon receptor signaling in HepG2 cells
NPDI-i4m0FA Cannabis (Cannabis sativa) Cannabis Characterization of Bulk Plant Material

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