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  • Cannabis (Cannabis sativa)

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ID Subject of Study Study Name Name Type Overall Effect Enzymes Transporters Object Object Metabolite Precipitant
NPDI-PxRYvA Cannabis (Cannabis sativa) Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids CBN-UGT1A10 In Vitro Enzyme Kinetics positive — In Vitro Detectable Kinetic Metabolism
  • UGT1A10
cannabinol (cbn) 11-hydroxycannabinol
NPDI-Qoqt5Q Cannabis (Cannabis sativa) Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids CBN-UGT1A7 In Vitro Enzyme Kinetics positive — In Vitro Detectable Kinetic Metabolism
  • UGT1A7
cannabinol (cbn) 11-hydroxycannabinol
NPDI-ToTRjw Cannabis (Cannabis sativa) Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids CBN-UGT1A8 In Vitro Enzyme Kinetics positive — In Vitro Detectable Kinetic Metabolism
  • UGT1A8
cannabinol (cbn) 11-hydroxycannabinol
NPDI-akOrWg Cannabis (Cannabis sativa) Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids CBN-UGT1A9 In Vitro Enzyme Kinetics positive — In Vitro Detectable Kinetic Metabolism
  • UGT1A9
cannabinol (cbn) 11-hydroxycannabinol
NPDI-ZNPhvw Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. iHLM: CBN-warfarin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
(s)-warfarin 7-hydroxywarfarin cannabinol (cbn)
NPDI-jwN2Vw Cannabis (Cannabis sativa) Involvement of UDP-Glucuronosyltransferases UGT1A9 and UGT2B7 in Ethanol Glucuronidation, and Interactions with Common Drugs of Abuse CBN-UGT1A9 Inhibition In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT1A9
ethanol ethyl glucuronide cannabinol (cbn)
NPDI-7hkXUg Cannabis (Cannabis sativa) Involvement of UDP-Glucuronosyltransferases UGT1A9 and UGT2B7 in Ethanol Glucuronidation, and Interactions with Common Drugs of Abuse CBN on ethanol glucuronidation In Vitro Enzyme Induction positive — In Vitro Enzyme Induction
  • UGT
cannabinol (cbn)
NPDI-JvqWDQ Cannabis (Cannabis sativa) Involvement of UDP-Glucuronosyltransferases UGT1A9 and UGT2B7 in Ethanol Glucuronidation, and Interactions with Common Drugs of Abuse CBN-UGT2B7 Induction In Vitro Enzyme Induction positive — In Vitro Enzyme Induction
  • UGT2B7
cannabinol (cbn)
NPDI-mGu2ew Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. pHLM: CBN-warfarin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
(s)-warfarin 7-hydroxywarfarin cannabinol (cbn)
NPDI-wt2yDg Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. rCYP2C9: CBN-warfarin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
(s)-warfarin 7-hydroxywarfarin cannabinol (cbn)
NPDI-V1SemA Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. iHLM: CBN-diclofenac In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
diclofenac 4'-hydroxydiclofenac cannabinol (cbn)
NPDI-KqafWg Cannabis (Cannabis sativa) Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. rCYP2C9: CBN-diclofenac In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
diclofenac 4'-hydroxydiclofenac cannabinol (cbn)
NPDI-b-kubA Cannabis (Cannabis sativa) Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. Recombinant: CBN-AMMC In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
3-[2-(n,n-diethyl-n-methylammonium)ethyl]-7-methoxy-4-methylcoumarin 3-[2-(n,n-diethyl-n-methylammonium)ethyl]-7-hydroxy-4-methylcoumarin cannabinol (cbn)
NPDI-0g58zw Cannabis (Cannabis sativa) Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. Recombinant: CBN-dextromethorphan In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
dextromethorphan dextrorphan cannabinol (cbn)
NPDI-p2jqFw Cannabis (Cannabis sativa) Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. pHLM: CBN-dextromethorphan In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
dextromethorphan dextrorphan cannabinol (cbn)
NPDI-ens_Gw Cannabis (Cannabis sativa) Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety. CYP3A4-CBN In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP3A4
diltiazem n-demethyldiltiazem cannabinol (cbn)
NPDI-yszOMw Cannabis (Cannabis sativa) Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety. HLM-CBN In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP3A
diltiazem n-demethyldiltiazem cannabinol (cbn)
NPDI-dsHL7w Cannabis (Cannabis sativa) The multidrug transporter ABCG2 (BCRP) is inhibited by plant-derived cannabinoids. Mitoxantrone-CBN In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • BCRP (ABCG2)
mitoxantrone cannabinol (cbn)
NPDI-v65nxg Cannabis (Cannabis sativa) Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes 1A1: CBN In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A1
7-ethoxyresorufin resorufin cannabinol (cbn)
NPDI-RC8Kxw Cannabis (Cannabis sativa) Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes 1A2: CBN In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A2
7-ethoxyresorufin resorufin cannabinol (cbn)
NPDI-XKoD2A Cannabis (Cannabis sativa) Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes HLMs: CBN In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A1
7-ethoxyresorufin resorufin cannabinol (cbn)
NPDI-G8_czw Cannabis (Cannabis sativa) The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells. CEM/VLB100: CBN In Vitro Transporter Inhibition negative — In Vitro Transporter Non-inhibition
  • P-gp (ABCB1)
rhodamine 123 cannabinol (cbn)
NPDI-EqzxjQ Cannabis (Cannabis sativa) The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells. CCRF-CEM: CBN In Vitro Transporter Inhibition negative — In Vitro Transporter Non-inhibition
  • P-gp (ABCB1)
rhodamine 123 cannabinol (cbn)
NPDI-soqMrQ Cannabis (Cannabis sativa) Cannabis Characterization of Bulk Plant Material Cannabis bulk plant Characterization of Material Characterization of Material

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