In Vitro Enzyme Inhibition Experiment

CBN-UGT1A9 Inhibition

Inhibition was detected.  Cutoff used — Not specified

ethanol

cannabinol (CBN)

ethyl glucuronide

  • UGT1A9

Cell system Human cryopreserved hepatocytes

Results

Compound measured Measurement Value Study sequence Additional information N replicates

Experimental Conditions

In-house preparation

100 μL

45 min

MgCl2

UDPGA

25 mM

5 min

No NADPH with no precipitant

0, 5, 10,15 mg/L