- Natural product: Cannabis (Cannabis sativa)
- Associated study: Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6.
In Vitro Enzyme Inhibition Experiment
Recombinant: CBN-AMMC
Inhibition was detected. Cutoff used — Not specified
- CYP2D6 4173631
Cell fraction Pooled human liver microsomes -7999662
Results
Table 1
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
2pmol
Commercially available
200 μL
30 min
MgCl2
NADPH regenerating system
0.24-15 μM
5 min
NADPH with precipitant