Inhibition of 8-hydroxylation of cannabinol by ketoconazole CSV JSON

In Vitro Enzyme Inhibition Experiment

Inhibition of 8-hydroxylation of cannabinol by ketoconazole

Inhibition was detected.  Cutoff used —

Not provided

cannabinol

ketoconazole

8-hydroxycannabinol

  • CYP3A

Cell fraction Pooled human liver microsomes -7999662

Results

Table 1

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

10 microG

Commercially available

20 min

NADPH
NADPH regenerating system

64 µM

10 µM