- Natural product: Cannabis (Cannabis sativa)
- Associated study: Cannabidiol induces expression of human cytochrome P450 1A1 that is possibly mediated through aryl hydrocarbon receptor signaling in HepG2 cells
In Vitro Enzyme Induction Experiment
Non-induction of CYP1A1 mRNA expression by 50 µM cannabinol
Non-induction was detected. Cutoff used —
"The significance of differences between the means of the various groups was evaluated by means of a one-way analysis of variance followed by Bonferroni or Dunnett's post-hoc test."
- CYP1A1 4173297
Cell system HepG2 cell line
Results
Estimated from Figure 2
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
mRNA expression
1000000 cells/well
Yes
0, 5, 10, 25, 50 µM
6 h
Platinum® SYBR® Green qPCR SuperMix-UDG qPCR (Invitrogen)