Negligible inhibition of ABCC1 by THC CSV JSON

In Vitro Transporter Inhibition Experiment

Negligible inhibition of ABCC1 by THC

Non-inhibition was detected.  Cutoff used —

Not provided. A common convention is that IC50 > 100 micM signals negligible inhibition

fluo3

delta-9-tetrahydrocannabinol

  • ABCC1

Cell system Human ABCC1 transduced subline (MRP1)

Results

“Measurements show 50% reduction in transport using increase in intracellular accumulation based on % of parent concentration”

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

“incubation time with two phases, cells and natural products for 30 min and then with Fluo3 for another 60 min”

Assay Conditions

1 µg/ml

0.08, 0.4, 2, 10, 50, 100 and 200 µM