Secobarbital Plasma Concentrations Following Sodium Secobarbital Ingestion and 500 µg/kg CBD Pretreatment CSV JSON
- Natural product: Cannabis (Cannabis sativa)
- Associated study: Influence of cannabidiol on secobarbital effects and plasma kinetics
In Vivo Interaction Study
Secobarbital Plasma Concentrations Following Sodium Secobarbital Ingestion and 500 µg/kg CBD Pretreatment
No Effect (based on bioequivalence limits) was detected.
Figure 1
Results
Values estimated from Figure 1. Original value was converted to ng/mL: Cmax (µg/mL): 2.75
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
Double-blind
Placebo-controlled
Single dosing
Healthy volunteers
Males
6
"No subjects used drugs or medication habitually, but all had previously smoked marijuana. Subjects were instructed to fast at least four hours prior to the experimental session and to eat a light breakfast consisting of dry toast and juice. [...] All sessions were separated by at least one week."
0, 15, 30, 45, 60, 75, 90, 105, 120, 150, 180, 210, 240, 270, 300 min, 24, 48, and 72 h
Drug or Natural Product Administration
Oral
Capsule
150 mg/70 kg
Once
Inhalation
Cigarette
500 µg/kg
Once
Not specified