In Vitro Transporter Inhibition Experiment


Inhibition was detected.  Cutoff used — "The mean accumulation index had to be significantly > 1 (p < 0.05) to assess transporter inhibition potency by flow cytometry (n = 3 minimum)."

rhodamine 123

  • P-gp (ABCB1)

Transfected / siRNA knock-out / injected cells HEK293 transfected cells


Fig 2b
PSC833 5 μM was used as a positive control

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

Assay Conditions

1.5 μM

50 μM