- Natural product: Cannabis (Cannabis sativa)
- Associated study: Predicting the Potential for Cannabinoids to Precipitate Pharmacokinetic Drug Interactions via Reversible Inhibition or Inactivation of Major Cytochromes P450
In Vitro Enzyme Inhibition Experiment
THC Inhibition on CYP3A
Inhibition was detected. Cutoff used —
Table 1 lists the oral and inhalational doses and estimated maximum plasma concentrations of CBD, THC, and THC metabolites used for predicting the magnitude of pharmacokinetic cannabinoid-drug interactions.
- CYP3A
Cell fraction Pooled human liver microsomes -7999662
Results
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
0.1 mg/ml
Commercially available
10 µM