Secobarbital Plasma Concentrations Following Sodium Secobarbital Ingestion and 150 µg/kg CBD Pretreatment CSV JSON

In Vivo Interaction Study

Secobarbital Plasma Concentrations Following Sodium Secobarbital Ingestion and 150 µg/kg CBD Pretreatment

No Effect (based on bioequivalence limits) was detected.

secobarbital

Figure 1

Results

Values estimated from Figure 1 and converted from µg/mL. Original estimated value: 2.5 µg/mL.

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

Double-blind
Placebo-controlled
Single dosing

Population

Healthy volunteers
Males

6

"No subjects used drugs or medication habitually, but all had previously smoked marijuana. Subjects were instructed to fast at least four hours prior to the experimental session and to eat a light breakfast consisting of dry toast and juice. [...] All sessions were separated by at least one week."

Pharmacokinetic (PK) Sampling Information

0, 15, 30, 45, 60, 75, 90, 105, 120, 150, 180, 210, 240, 270, 300 min, 24, 48, and 72 h

Drug or Natural Product Administration

Object Administration — secobarbital

Oral

Capsule

150 mg/70 kg

Once

Precipitant Administration — delta-9-tetrahydrocannabinol (thc)

Inhalation

Cigarette

150 µg/kg

Once

Natural Product Characteristics

Not specified