In Vitro Enzyme Inhibition Experiment

11-OH-THC Inhibition on CYP2D6

Inhibition was detected.  Cutoff used —

Table 1 lists the oral and inhalational doses and estimated maximum plasma concentrations of CBD, THC, and THC metabolites used for predicting the magnitude of pharmacokinetic cannabinoid-drug interactions. 

dextromethorphan 1119510

11-hydroxy-delta-9-tetrahydrocannabinol

dextrorphan 4349487

  • CYP2D6 4173631

Cell fraction Pooled human liver microsomes -7999662

Results

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

0.1 mg/ml

Commercially available

5 µM