- Natural product: Cannabis (Cannabis sativa)
- Associated study: Predicting the Potential for Cannabinoids to Precipitate Pharmacokinetic Drug Interactions via Reversible Inhibition or Inactivation of Major Cytochromes P450
In Vitro Enzyme Inhibition Experiment
11-OH-THC Inhibition on CYP3A
Inhibition was detected. Cutoff used —
Table 1 lists the oral and inhalational doses and estimated maximum plasma concentrations of CBD, THC, and THC metabolites used for predicting the magnitude of pharmacokinetic cannabinoid-drug interactions.
- CYP3A
Cell fraction Pooled human liver microsomes -7999662
Results
IC50 > 50
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
0.1 mg/ml
Commercially available
10 µM