3A4 Inhibition by Berberine CSV JSON

In Vitro Enzyme Inhibition Experiment

3A4 Inhibition by Berberine

Inhibition was detected.  Cutoff used — not specified

testosterone

Berberine 19012197

6beta-Hydroxytestosterone

  • CYP3A4 4306811

Cell fraction Pooled human liver microsomes -7999662

Results

Estimate at 500 μM (Fig 4a)

Compound measured Measurement Value Study sequence Additional information N replicates

Experimental Conditions

0.2 mg/mL

Commercially available

15 min

NADPH

200 μ􏱂M

No NADPH with precipitant

10, 100, and 500 μ􏱂M