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  • Goldenseal (Hydrastis canadensis)

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ID Subject of Study Study Name Name Type Overall Effect Enzymes Transporters Object Object Metabolite Precipitant
NPDI-FWZOMQ Goldenseal (Hydrastis canadensis) Tetrandrine Potentiates the Hypoglycemic Efficacy of Berberine by Inhibiting P-Glycoprotein Function Reduced Efflux of Berberine Through P-gp In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • P-gp (ABCB1)
berberine tetrandrine
NPDI-mUlTOw Goldenseal (Hydrastis canadensis) Organic anion-transporting polypeptides contribute to the hepatic uptake of berberine BBR-OATP1B1 In Vitro Transporter Kinetics negative — No In Vitro Transport Activity
  • OATP1B1 (SLCO1B1)
berberine
NPDI-oYawZw Goldenseal (Hydrastis canadensis) Poor permeability and absorption affect the activity of four alkaloids from Coptis P-gp Permeability of Berberine Induced by Verapamil In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • P-gp (ABCB1)
berberine verapamil
NPDI-kt6jEg Goldenseal (Hydrastis canadensis) Organic anion-transporting polypeptides contribute to the hepatic uptake of berberine Transport of Berberine by OAT1B3 In Vitro Transporter Kinetics positive — In Vitro Transport
  • OATP1B3 (SLCO1B3)
berberine
NPDI-2ugVjg Goldenseal (Hydrastis canadensis) Poor permeability and absorption affect the activity of four alkaloids from Coptis Efflux of Berberine through P-gp In Vitro Transporter Kinetics negative — No In Vitro Transport Activity
  • P-gp (ABCB1)
berberine
NPDI-3z4F5w Goldenseal (Hydrastis canadensis) Inhibition of P-Glycoprotein by HIV Protease Inhibitors Increases Intracellular Accumulation of Berberine in Murine and Human Macrophages Amprenavir P-gp Inhibition In Vitro Transporter Kinetics positive — In Vitro Transport
  • P-gp (ABCB1)
berberine
NPDI-zv6CYw Goldenseal (Hydrastis canadensis) Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1) Berberine Transport by OCT1 In Vitro Transporter Kinetics positive — In Vitro Transport
  • OCT1 (SLC22A1)
berberine
NPDI-a3Bf6g Goldenseal (Hydrastis canadensis) Inhibition of P-Glycoprotein by HIV Protease Inhibitors Increases Intracellular Accumulation of Berberine in Murine and Human Macrophages Ritonavir P-gp Inhibition In Vitro Transporter Kinetics positive — In Vitro Transport
  • P-gp (ABCB1)
berberine
NPDI-VpSvoQ Goldenseal (Hydrastis canadensis) Inhibition of P-Glycoprotein by HIV Protease Inhibitors Increases Intracellular Accumulation of Berberine in Murine and Human Macrophages Lopinavir P-gp Inhibition In Vitro Transporter Kinetics positive — In Vitro Transport
  • P-gp (ABCB1)
berberine
NPDI-5R4-8g Goldenseal (Hydrastis canadensis) Inhibition of organic cation transporter 2 and 3 may be involved in the mechanism of the antidepressant-like action of berberine Berberine Transport by OCT2 In Vitro Transporter Kinetics positive — In Vitro Transport
  • OCT2 (SLC22A2)
berberine
NPDI-PeLrDg Goldenseal (Hydrastis canadensis) Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1) Berberine Transport by OCT2 In Vitro Transporter Kinetics positive — In Vitro Transport
  • OCT2 (SLC22A2)
berberine
NPDI-d4PkwQ Goldenseal (Hydrastis canadensis) Human MDR1 and MRP1 Recognize Berberine as Their Transport Substrate Berberine Transport by P-gp In Vitro Transporter Kinetics positive — In Vitro Transport
  • P-gp (ABCB1)
berberine
NPDI-IXEC2g Goldenseal (Hydrastis canadensis) Human MDR1 and MRP1 Recognize Berberine as Their Transport Substrate Control P-gp In Vitro Transporter Kinetics (Control experiment) positive — In Vitro Transport
  • P-gp (ABCB1)
berberine
NPDI-ldcSbA Goldenseal (Hydrastis canadensis) Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1) P-gp Transport of Berberine In Vitro Transporter Kinetics positive — In Vitro Transport
  • P-gp (ABCB1)
berberine
NPDI-ZdbG7w Goldenseal (Hydrastis canadensis) The Effect of Oxidation on Berberine-Mediated CYP1 Inhibition: Oxidation Behavior and Metabolite-Mediated Inhibition CYP1A2 preincubation w/o NADPH In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP1A2
7-ethoxyresorufin resorufin berberine
NPDI-YlLZrw Goldenseal (Hydrastis canadensis) Identification of novel dietary phytochemicals inhibiting the efflux transporter breast cancer resistance protein (BCRP/ABCG2) Inhibition of BCRP by Berberine In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • BCRP (ABCG2)
mitoxantrone berberine
NPDI-gJxFZQ Goldenseal (Hydrastis canadensis) Inhibition of organic cation transporter 2 and 3 may be involved in the mechanism of the antidepressant-like action of berberine OCT2 Inhibition by Berberine (5-HT) In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • OCT2 (SLC22A2)
serotonin berberine
NPDI-c2kfPA Goldenseal (Hydrastis canadensis) An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents 2C19 Inhibition by Berberine In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- berberine
NPDI-NAiMNw Goldenseal (Hydrastis canadensis) The Effect of Oxidation on Berberine-Mediated CYP1 Inhibition: Oxidation Behavior and Metabolite-Mediated Inhibition Pre-incubation w/o NADPH In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP1A1
7-ethoxyresorufin resorufin berberine
NPDI-jrKjdQ Goldenseal (Hydrastis canadensis) Differential inhibition of CYP1-catalyzed regioselective hydroxylation of estradiol by berberine and its oxidative metabolites CYP1A2 Inhibition by Berberine In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A2
17-beta-estradiol 2-hydroxyestradiol berberine
NPDI-q61pww Goldenseal (Hydrastis canadensis) Inhibitory Mechanisms of Human CYPs by Three Alkaloids Isolated from Traditional Chinese Herbs 3A4 preincubation with NADPH In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
testosterone 6beta-hydroxytestosterone berberine
NPDI-MsX4aw Goldenseal (Hydrastis canadensis) Inhibitory Mechanisms of Human CYPs by Three Alkaloids Isolated from Traditional Chinese Herbs 1A2 preincubation without NADPH In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A2
testosterone 6beta-hydroxytestosterone berberine
NPDI-wjO31A Goldenseal (Hydrastis canadensis) Inhibitory Mechanisms of Human CYPs by Three Alkaloids Isolated from Traditional Chinese Herbs 2D6 preincubation without NADPH In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
testosterone 6beta-hydroxytestosterone berberine
NPDI-nzhlHQ Goldenseal (Hydrastis canadensis) Repeated administration of berberine inhibits cytochromes P450 in humans CYP2C19 Experiment In Vivo Interaction negative — No Effect (based on bioequivalence limits)
  • CYP2C19
omeprazole berberine
NPDI-3VbSWA Goldenseal (Hydrastis canadensis) Repeated administration of berberine inhibits cytochromes P450 in humans CYP1A2 Experiment In Vivo Interaction negative — No Effect (based on bioequivalence limits)
  • CYP1A2
caffeine berberine
NPDI-j7Vnlw Goldenseal (Hydrastis canadensis) Repeated administration of berberine inhibits cytochromes P450 in humans CYP3A4 Experiment In Vivo Interaction positive — PK Interaction - Increased systemic exposure
  • CYP3A4
midazolam berberine
NPDI-M8kbsQ Goldenseal (Hydrastis canadensis) Repeated administration of berberine inhibits cytochromes P450 in humans CYP2C9 Experiment In Vivo Interaction positive — PK Interaction - Increased systemic exposure
  • CYP2C9
losartan berberine
NPDI-FJjrAg Goldenseal (Hydrastis canadensis) The Effects of Berberine on the Pharmacokinetics of Ciclosporin A in Healthy Volunteers CsA 6 mg/kg Experiment In Vivo Interaction negative — No Effect (based on bioequivalence limits)
  • CYP3A4
  • P-gp (ABCB1)
cyclosporin a berberine
NPDI-jjh4MA Goldenseal (Hydrastis canadensis) The Effect of Oxidation on Berberine-Mediated CYP1 Inhibition: Oxidation Behavior and Metabolite-Mediated Inhibition 1A2 pre-incubation with NADPH In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP1A2
7-ethoxyresorufin resorufin berberine
NPDI-8px6rQ Goldenseal (Hydrastis canadensis) Repeated administration of berberine inhibits cytochromes P450 in humans CYP2D6 Experiment In Vivo Interaction positive — PK Interaction - Increased systemic exposure
  • CYP2D6
dextromethorphan berberine
NPDI-FANNaQ Goldenseal (Hydrastis canadensis) Differential inhibition of CYP1-catalyzed regioselective hydroxylation of estradiol by berberine and its oxidative metabolites CYP1A1 Inhibition by Berberine In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A1
17-beta-estradiol 2-hydroxyestradiol berberine
NPDI-uJn2xw Goldenseal (Hydrastis canadensis) Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study CsA in Renal Transplant patients In Vivo Interaction positive — PK Interaction - Increased systemic exposure
cyclosporin a berberine
NPDI-C2C-Nw Goldenseal (Hydrastis canadensis) Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study CsA Trough measurements in 52 patients In Vivo Interaction positive — PK Interaction - Increased systemic exposure
cyclosporin a berberine
NPDI-6IV4Kg Goldenseal (Hydrastis canadensis) The Effects of Berberine on the Pharmacokinetics of Ciclosporin A in Healthy Volunteers CsA 3 mg/kg Experiement In Vivo Interaction positive — PK Interaction - Increased systemic exposure
  • CYP3A4
  • P-gp (ABCB1)
cyclosporin a berberine
NPDI-5sDXyA Goldenseal (Hydrastis canadensis) The Effect of Oxidation on Berberine-Mediated CYP1 Inhibition: Oxidation Behavior and Metabolite-Mediated Inhibition CYP1A1 preincubation with NADPH In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP1A1
7-ethoxyresorufin resorufin berberine
NPDI-ykfGxQ Goldenseal (Hydrastis canadensis) Inhibitory Mechanisms of Human CYPs by Three Alkaloids Isolated from Traditional Chinese Herbs 2D6 pre-incubation with NADPH In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
testosterone 6beta-hydroxytestosterone berberine
NPDI-iBWK6Q Goldenseal (Hydrastis canadensis) Inhibitory Mechanisms of Human CYPs by Three Alkaloids Isolated from Traditional Chinese Herbs 3A4 preincubation without NADPH In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
testosterone 6beta-hydroxytestosterone berberine
NPDI-EjO7dA Goldenseal (Hydrastis canadensis) Inhibitory Mechanisms of Human CYPs by Three Alkaloids Isolated from Traditional Chinese Herbs 1A2 preincubation with NADPH In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A2
testosterone 6beta-hydroxytestosterone berberine
NPDI-roGv8w Goldenseal (Hydrastis canadensis) Time-Dependent Inhibition of CYP2C19 by Isoquinoline Alkaloids: In Vitro and In Silico Analysis CYP2C19 Inhibition by Berberine In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2C19
dibenzylfluorescein fluorescein berberine
NPDI-rR-2qg Goldenseal (Hydrastis canadensis) Inhibition of organic cation transporter 2 and 3 may be involved in the mechanism of the antidepressant-like action of berberine OCT2 Inhibition by Berberine (NE) In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • OCT2 (SLC22A2)
norepinephrine berberine
NPDI-KGE4lw Goldenseal (Hydrastis canadensis) An ex vivo approach to botanical-drug interactions: A proof of concept study 3A4/5 Inhibition by Berberine (Plasma) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A
midazolam 1'-hydroxymidazolam berberine
NPDI-PaRJNQ Goldenseal (Hydrastis canadensis) An ex vivo approach to botanical-drug interactions: A proof of concept study 3A4/5 Inhibition by Berberine (PB) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A
midazolam 1'-hydroxymidazolam berberine
NPDI-Wkqo4w Goldenseal (Hydrastis canadensis) Effects of Herbal Products and their Constituents on Human Cytochrome P4502E1 Activity CYP2E1 Inhibition by Berberine In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2E1
p-nitrophenol 4-nitrophenyl sulfate berberine
NPDI-2kECKw Goldenseal (Hydrastis canadensis) An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents 2C8 Inhibition by Berberine In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2C8
paclitaxel 6-alpha-hydroxy paclitaxel berberine
NPDI-cRrAsg Goldenseal (Hydrastis canadensis) An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents 2D6 Inhibition by Berberine In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
dextromethorphan dextrorphan berberine
NPDI-ij84RA Goldenseal (Hydrastis canadensis) An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents 2E1 Inhibition by Berberine In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2E1
p-nitrophenol 4-nitrophenyl sulfate berberine
NPDI-1ijwVg Goldenseal (Hydrastis canadensis) An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents 3A4 Inhibition by Berberine (Testosterone) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
testosterone 6beta-hydroxytestosterone berberine
NPDI-iSHQYQ Goldenseal (Hydrastis canadensis) Human Cytochrome P450 Inhibition and Metabolic-Intermediate Complex Formation By Goldenseal Extract and Its Methylenedioxyphenyl Components 2C9 Inhibition by Berberine In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
diclofenac 4'-hydroxydiclofenac berberine
NPDI-_D6yiA Goldenseal (Hydrastis canadensis) Human Cytochrome P450 Inhibition and Metabolic-Intermediate Complex Formation By Goldenseal Extract and Its Methylenedioxyphenyl Components 3A4 Inhibition by Berberine In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
testosterone 6beta-hydroxytestosterone berberine
NPDI-LNDazQ Goldenseal (Hydrastis canadensis) Human Cytochrome P450 Inhibition and Metabolic-Intermediate Complex Formation By Goldenseal Extract and Its Methylenedioxyphenyl Components 2D6 Inhibition by Berberine In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
bufuralol 1'-hydroxybufuralol berberine
NPDI-OFFj8Q Goldenseal (Hydrastis canadensis) An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures 3A4 Inhibition by Berberine In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
7-ethoxyresorufin resorufin berberine
NPDI-9t7UTw Goldenseal (Hydrastis canadensis) Goldenseal Characterization of Material Goldenseal Characterization of Material Experiment Characterization of Material
ID Subject of Study Name
NPDI-rREhEQ Goldenseal (Hydrastis canadensis) Tetrandrine Potentiates the Hypoglycemic Efficacy of Berberine by Inhibiting P-Glycoprotein Function
NPDI-hKjwcg Goldenseal (Hydrastis canadensis) Organic anion-transporting polypeptides contribute to the hepatic uptake of berberine
NPDI-C-vzvw Goldenseal (Hydrastis canadensis) Poor permeability and absorption affect the activity of four alkaloids from Coptis
NPDI-uO_CeA Goldenseal (Hydrastis canadensis) Inhibition of P-Glycoprotein by HIV Protease Inhibitors Increases Intracellular Accumulation of Berberine in Murine and Human Macrophages
NPDI-ZfxNfg Goldenseal (Hydrastis canadensis) Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1)
NPDI-rRRoQw Goldenseal (Hydrastis canadensis) Inhibition of organic cation transporter 2 and 3 may be involved in the mechanism of the antidepressant-like action of berberine
NPDI-dBrDOg Goldenseal (Hydrastis canadensis) Human MDR1 and MRP1 Recognize Berberine as Their Transport Substrate
NPDI-5Mf9Qw Goldenseal (Hydrastis canadensis) The Effect of Oxidation on Berberine-Mediated CYP1 Inhibition: Oxidation Behavior and Metabolite-Mediated Inhibition
NPDI--aO6Bw Goldenseal (Hydrastis canadensis) Identification of novel dietary phytochemicals inhibiting the efflux transporter breast cancer resistance protein (BCRP/ABCG2)
NPDI-EiXGKA Goldenseal (Hydrastis canadensis) An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents
NPDI-jEZ9Ng Goldenseal (Hydrastis canadensis) Differential inhibition of CYP1-catalyzed regioselective hydroxylation of estradiol by berberine and its oxidative metabolites
NPDI-JcMOhg Goldenseal (Hydrastis canadensis) Inhibitory Mechanisms of Human CYPs by Three Alkaloids Isolated from Traditional Chinese Herbs
NPDI-5XFThQ Goldenseal (Hydrastis canadensis) Repeated administration of berberine inhibits cytochromes P450 in humans
NPDI-yBr48Q Goldenseal (Hydrastis canadensis) The Effects of Berberine on the Pharmacokinetics of Ciclosporin A in Healthy Volunteers
NPDI-rmRb0A Goldenseal (Hydrastis canadensis) Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study
NPDI-4zmpGg Goldenseal (Hydrastis canadensis) Time-Dependent Inhibition of CYP2C19 by Isoquinoline Alkaloids: In Vitro and In Silico Analysis
NPDI-luckpg Goldenseal (Hydrastis canadensis) An ex vivo approach to botanical-drug interactions: A proof of concept study
NPDI-47DSLg Goldenseal (Hydrastis canadensis) Effects of Herbal Products and their Constituents on Human Cytochrome P4502E1 Activity
NPDI-agZaLg Goldenseal (Hydrastis canadensis) Human Cytochrome P450 Inhibition and Metabolic-Intermediate Complex Formation By Goldenseal Extract and Its Methylenedioxyphenyl Components
NPDI-pHkLHA Goldenseal (Hydrastis canadensis) An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures
NPDI-Em0b2g Goldenseal (Hydrastis canadensis) Goldenseal Characterization of Material

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