CYP2C9 Experiment CSV JSON

In Vivo Interaction Study

CYP2C9 Experiment

Increased systemic exposure was detected.

losartan

berberine 19012197

  • CYP2C9 4309227

Results

Table 1 - Note above is CHANGE FROM CONTROL percent while the paper reports a ratio percent of the two values

Sample Compound measured Measurement Value Study sequence Additional information N replicates

Experimental Conditions

Double-blind
Placebo-controlled
Randomized crossover
Multiple dosing

Population

Healthy volunteers
Males

No alcohol drinking
Nonsmokers

Asian

17

Chinese

Pharmacokinetic (PK) Sampling Information

Urine samples of 0–4, 4–8, 8– 12 h

Drug or Natural Product Administration

Object Administration — losartan

Oral

Tablet

30 mg

Once daily

14 days administered at 8 AM with first daily dose of precipitant

Precipitant Administration — berberine

Oral

Capsule

900 mg

300 mg three times daily

14 days

Natural Product Characteristics

Yunnan Baiyao Group Dali Pharmaceutical, Yunnan, China

2011