- Natural product: Goldenseal (Hydrastis canadensis)
- Associated study: Repeated administration of berberine inhibits cytochromes P450 in humans
In Vivo Interaction Study
CYP2C9 Experiment
Increased systemic exposure was detected.
- CYP2C9 4309227
Results
Table 1 - Note above is CHANGE FROM CONTROL percent while the paper reports a ratio percent of the two values
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
Double-blind
Placebo-controlled
Randomized crossover
Multiple dosing
Healthy volunteers
Males
No alcohol drinking
Nonsmokers
Asian
17
Chinese
Urine samples of 0–4, 4–8, 8– 12 h
Drug or Natural Product Administration
Oral
Tablet
30 mg
Once daily
14 days administered at 8 AM with first daily dose of precipitant
Oral
Capsule
900 mg
300 mg three times daily
14 days
Yunnan Baiyao Group Dali Pharmaceutical, Yunnan, China
2011