Need public description.


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None listed

None listed

None listed
ID Subject of Study Study Name Name Type Overall Effect Enzymes Transporters Object Object Metabolite Precipitant
NPDI-FJjrAg Goldenseal (Hydrastis canadensis) The Effects of Berberine on the Pharmacokinetics of Ciclosporin A in Healthy Volunteers CsA 6 mg/kg Experiment In Vivo Interaction negative — No Effect (based on bioequivalence limits)
  • CYP3A4
  • P-gp (ABCB1)
cyclosporin a berberine
NPDI-uJn2xw Goldenseal (Hydrastis canadensis) Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study CsA in Renal Transplant patients In Vivo Interaction positive — PK Interaction - Increased systemic exposure
cyclosporin a berberine
NPDI-C2C-Nw Goldenseal (Hydrastis canadensis) Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study CsA Trough measurements in 52 patients In Vivo Interaction positive — PK Interaction - Increased systemic exposure
cyclosporin a berberine
NPDI-6IV4Kg Goldenseal (Hydrastis canadensis) The Effects of Berberine on the Pharmacokinetics of Ciclosporin A in Healthy Volunteers CsA 3 mg/kg Experiement In Vivo Interaction positive — PK Interaction - Increased systemic exposure
  • CYP3A4
  • P-gp (ABCB1)
cyclosporin a berberine

Compound information from external resources

Resource Identifier
Google search PMATZTZNYRCHOR-CGLBZJNRSA-N