NaPDI | Compound details

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Natural products containing this compound

Enantiomer of compound
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Compound has enantiomers
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Metabolite of compounds
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Compound has metabolites
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ID	Subject of Study	Study Name	Name	Type	Overall Effect	Enzymes	Transporters	Object	Object Metabolite	Precipitant
NPDI-C2C-Nw	Goldenseal (Hydrastis canadensis)	Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study	CsA Trough measurements in 52 patients	In Vivo Interaction	positive — PK Interaction - Increased systemic exposure			cyclosporin a		berberine
NPDI-uJn2xw	Goldenseal (Hydrastis canadensis)	Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study	CsA in Renal Transplant patients	In Vivo Interaction	positive — PK Interaction - Increased systemic exposure			cyclosporin a		berberine
NPDI-6IV4Kg	Goldenseal (Hydrastis canadensis)	The Effects of Berberine on the Pharmacokinetics of Ciclosporin A in Healthy Volunteers	CsA 3 mg/kg Experiement	In Vivo Interaction	positive — PK Interaction - Increased systemic exposure	CYP3A4	P-gp (ABCB1)	cyclosporin a		berberine
NPDI-FJjrAg	Goldenseal (Hydrastis canadensis)	The Effects of Berberine on the Pharmacokinetics of Ciclosporin A in Healthy Volunteers	CsA 6 mg/kg Experiment	In Vivo Interaction	negative — No Effect (based on bioequivalence limits)	CYP3A4	P-gp (ABCB1)	cyclosporin a		berberine

ID	Subject of Study	Name
NPDI-rmRb0A	Goldenseal (Hydrastis canadensis)	Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study
NPDI-yBr48Q	Goldenseal (Hydrastis canadensis)	The Effects of Berberine on the Pharmacokinetics of Ciclosporin A in Healthy Volunteers

Compound information from external resources

Resource	Identifier
Google search	PMATZTZNYRCHOR-CGLBZJNRSA-N