CsA Trough measurements in 52 patients CSV JSON

In Vivo Interaction Study

CsA Trough measurements in 52 patients

Increased systemic exposure was detected.

cyclosporin a

berberine 19012197

Results

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

Parallel
Multiple dosing

Population

Females
Males
Patients

52

Characteristics:

Age (years) 42.5±10.8
Body weight (kg) 55.3±10.2
Body mass index (kg/m2) 20.5±3.4
Sex (male/female) 31/21
Cyclosporin A dosage (mg/day) 319.2±90.7
Duration of cyclosporin A (months)  2.7±2.4
Azathioprine (mg/day) 43.4±17.4 
Prednisone (mg/day)  12.0±4.1

 

Pharmacokinetic (PK) Sampling Information

0, 2, 4, 6, 8,10, 12 hours

Drug or Natural Product Administration

Object Administration — cyclosporin a

Oral

capsule

6 mg/kg

Twice Daily

3 months

Precipitant Administration — berberine

Oral

tablet

600 mg

three times daily

3 months

Natural Product Characteristics

unspecified