CsA Trough measurements in 52 patients CSV JSON

Natural product: Goldenseal (Hydrastis canadensis)
Associated study: Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study

In Vivo Interaction Study

CsA Trough measurements in 52 patients

Increased systemic exposure was detected.

Object compound

cyclosporin a

Precipitant

berberine 19012197

Results

Sample	Compound measured	Value	Measurement	Study sequence	Additional information	N replicates

Experimental Conditions

Study design

Parallel
Multiple dosing

Population

Demographic characteristics

Females
Males
Patients

Number of subjects

Population additional information

Characteristics:

Age (years) 42.5±10.8
Body weight (kg) 55.3±10.2
Body mass index (kg/m2) 20.5±3.4
Sex (male/female) 31/21
Cyclosporin A dosage (mg/day) 319.2±90.7
Duration of cyclosporin A (months) 2.7±2.4
Azathioprine (mg/day) 43.4±17.4
Prednisone (mg/day) 12.0±4.1

Pharmacokinetic (PK) Sampling Information

Times of PK samples for object

0, 2, 4, 6, 8,10, 12 hours

Drug or Natural Product Administration

Object Administration — cyclosporin a

Administration route

Oral

Formulation

capsule

Total daily dose

6 mg/kg

Interval/frequency

Twice Daily

Duration

3 months

Precipitant Administration — berberine

Administration route

Oral

Formulation

tablet

Total daily dose

600 mg

Interval/frequency

three times daily

Duration

3 months

Natural Product Characteristics

Year sourcing was completed

unspecified

NOTE