- Natural product: Goldenseal (Hydrastis canadensis)
- Associated study: Differential inhibition of CYP1-catalyzed regioselective hydroxylation of estradiol by berberine and its oxidative metabolites
In Vitro Enzyme Inhibition Experiment
CYP1A1 Inhibition by Berberine
Inhibition was detected. Cutoff used — not specified
- CYP1A1 4173297
Recombinant expression system E.coli
Cytochrome B5 Not available
Variants studied 1A1.1 1A2.1
Results
Table 1
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
NADPH regenerating system
50 μM