3A4 Inhibition by Berberine CSV JSON

In Vitro Enzyme Inhibition Experiment

3A4 Inhibition by Berberine

Inhibition was detected.  Cutoff used — not specified

7-ethoxyresorufin -7999995

berberine 19012197

resorufin -7999853

  • CYP3A4 4306811

Recombinant expression system Baculovirus-insect cells
Cytochrome B5 Not available


IC50 from Table 2: converted from mM (5.72 mM)
% inhibition from Table 1 (percent of full strength)
p (1 tail)

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

30 μL/mL

200 μL

1 h

1.5 mg/mL

10 min

NADPH with no precipitant

3 dilutions

62.5 μg/mL