- Natural product: Goldenseal (Hydrastis canadensis)
- Associated study: An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents
In Vitro Enzyme Inhibition Experiment
2C19 Inhibition by Berberine
Negligible Inhibition was detected. Cutoff used — not specified
- CYP2C19 4311137
Cell fraction Pooled human liver microsomes -7999662
Results
estimate from Fig 1 at 20 μM
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
In-house preparation
HHM-247 and HHM-258
15 min
NADPH
10 min
No NADPH with precipitant
1 or 20 μM