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ID Subject of Study Study Name Name Type Overall Effect Enzymes Transporters Object Object Metabolite Precipitant
NPDI-DtSHuA Licorice (Glycyrrhiza glabra) Cytochrome P450 inhibition by licorice species Glycyrrhiza glabra L. and fourteen licorice constituents Inhibition of CYP2C19 by Licorice extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- ethanolic extract of licorice g. glabra
NPDI-c03hqA Licorice (Glycyrrhiza uralensis) Cytochrome P450 inhibition by licorice species Glycyrrhiza uralensis and fourteen licorice constituents Inhibition of CYP2C19 by Licorice extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- ethanolic extract of licorice g. uralensis
NPDI-c2kfPA Goldenseal (Hydrastis canadensis) An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents 2C19 Inhibition by Berberine In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- berberine
NPDI-cXHH7g Green Tea (Camellia sinensis) Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes Inhibition of CYP2C19 by (-)-Epigallocatechin Gallate in HLM (IC50 Determination) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- (-)-epigallocatechin gallate
NPDI-YR9AgQ Green Tea (Camellia sinensis) Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes Inhibition of CYP2C19 by (-)-Epigallocatechin Gallate in HLM (Ki Determination) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- (-)-epigallocatechin gallate
NPDI-egkFFQ Cannabis (Cannabis sativa) Cannabidiol Is a Potent Inhibitor of the Catalytic Activity of Cytochrome P450 2C19 2H-CBD-(S)-Mephenytoin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- 8,9-dihydrocannabidiol
NPDI-8HM-ew Cannabis (Cannabis sativa) Cannabidiol Is a Potent Inhibitor of the Catalytic Activity of Cytochrome P450 2C19 CBDD-(S)-mephenytoin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- cannabidiol-dimethyl ether
NPDI-w7jBLw Cannabis (Cannabis sativa) Cannabidiol Is a Potent Inhibitor of the Catalytic Activity of Cytochrome P450 2C19 CBDM-(S)-Mephenytoin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- cannabidiol-2'-monomethyl ether
NPDI-k7I3rg Cannabis (Cannabis sativa) Cannabidiol Is a Potent Inhibitor of the Catalytic Activity of Cytochrome P450 2C19 CBDV-(S)-Mephenytoin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- cannabidivarin
NPDI-es-pWA Cannabis (Cannabis sativa) Cannabidiol Is a Potent Inhibitor of the Catalytic Activity of Cytochrome P450 2C19 CBD-(S)-Mephenytoin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- cannabidiol (cbd)
NPDI-FGSLRQ Cannabis (Cannabis sativa) Cannabidiol Is a Potent Inhibitor of the Catalytic Activity of Cytochrome P450 2C19 THC-(S)-Mephenytoin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- delta-9-tetrahydrocannabinol (thc)
NPDI-3QKJaw Goldenseal (Hydrastis canadensis) An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents 2C19 Inhibition by Ethanolic GS Extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- ethanolic goldenseal extract
NPDI-0_ey6g Goldenseal (Hydrastis canadensis) An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents 2C19 Inhibition by Aq GS Extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- aqueous goldenseal extract
NPDI-6cuc3g Goldenseal (Hydrastis canadensis) An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents 2C19 Inhibition by Hydrastine In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- hydrastine
NPDI-jqgbyA glycycoumarin Inhibition of CYP enzymes by glycycoumarin Inhibition of CYP2C19 by Glycycoumarin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- glycycoumarin

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