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ID Subject of Study Study Name Name Type Overall Effect Enzymes Transporters Object Object Metabolite Precipitant
NPDI-DtSHuA Licorice (Glycyrrhiza glabra) Cytochrome P450 inhibition by licorice species Glycyrrhiza glabra L. and fourteen licorice constituents Inhibition of CYP2C19 by G. glabra Licorice extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- ethanolic extract of licorice g. glabra
NPDI-gQk-ng licoricidin Inhibition of CYP enzymes by licoricidin Inhibition of CYP2C19 by Licoricidin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- licoricidin
NPDI-c03hqA Licorice (Glycyrrhiza uralensis) Cytochrome P450 inhibition by licorice species Glycyrrhiza uralensis and fourteen licorice constituents Inhibition of CYP2C19 by G. uralensis Licorice extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- ethanolic extract of licorice g. uralensis
NPDI-Z_m2jA Cannabis (Cannabis sativa) Cannabidiol is a potent inhibitor of the catalytic activity of cytochrome P450 2C19. Inhibition of CYP2C19 enzyme with Cannabidiol In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- cannabidiol
NPDI-9kN5_g Cannabis (Cannabis sativa) Cannabidiol is a potent inhibitor of the catalytic activity of cytochrome P450 2C19. Inhibition of CYP2C19 by Cannabidiol In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- cannabidiol
NPDI-GEE68Q Cannabis (Cannabis sativa) Cannabidiol is a potent inhibitor of the catalytic activity of cytochrome P450 2C19. Inhibition of CYP2C19 by Cannabidiol In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- cannabidiol
NPDI-hR5T0g Licorice (Glycyrrhiza inflata) Cytochrome P450 inhibition by licorice species Glycyrrhiza inflata and fourteen licorice constituents Inhibition of CYP2C19 by G. inflata Licorice extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- ethanolic extract of licorice g. inflata
NPDI-c2kfPA Goldenseal (Hydrastis canadensis) An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents 2C19 Inhibition by Berberine In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- berberine
NPDI-cXHH7g Green Tea (Camellia sinensis) Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes Inhibition of CYP2C19 by (-)-Epigallocatechin Gallate in HLM (IC50 Determination) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- (-)-epigallocatechin gallate
NPDI-YR9AgQ Green Tea (Camellia sinensis) Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes Inhibition of CYP2C19 by (-)-Epigallocatechin Gallate in HLM (Ki Determination) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- (-)-epigallocatechin gallate
NPDI-3QKJaw Goldenseal (Hydrastis canadensis) An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents 2C19 Inhibition by Ethanolic GS Extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- ethanolic goldenseal extract
NPDI-0_ey6g Goldenseal (Hydrastis canadensis) An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents 2C19 Inhibition by Aq GS Extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- aqueous goldenseal extract
NPDI-6cuc3g Goldenseal (Hydrastis canadensis) An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents 2C19 Inhibition by Hydrastine In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- hydrastine
NPDI-jqgbyA glycycoumarin Inhibition of CYP enzymes by glycycoumarin Inhibition of CYP2C19 by Glycycoumarin In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- glycycoumarin
NPDI-HNpTng licochalcone a Inhibition of CYP enzymes by licochalcone a Inhibition of CYP2C19 by Licochalcone A In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- licochalcone a
NPDI-eMZPbA Kratom (Mitragyna speciosa) Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids Inhibition of 7-hydroxymitragynine for CYP2C19 In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- 7-hydroxymitragynine
NPDI-gxj_UA Kratom (Mitragyna speciosa) Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids Control Positive Inhibition for CYP2C19 In Vitro Enzyme Inhibition (Control experiment) positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- (s)-(+)-n-3-benzylnirvanol
NPDI-Ua1CeQ Kratom (Mitragyna speciosa) Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids Inhibition of Mitragynine for CYP2C19 In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- mitragynine
NPDI-wo-wRw Kratom (Mitragyna speciosa) Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids Inhibition of Paynantheine for CYP2C19 In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- paynantheine
NPDI-aGXuxA Kratom (Mitragyna speciosa) Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids Weak Inhibition of Corynantheidine for CYP2C19 In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- corynantheidine
NPDI-WIpfxQ Kratom (Mitragyna speciosa) Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids Inhibition of Speicogynine for CYP2C19 In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- speciogynine
NPDI-XQCOGw Kratom (Mitragyna speciosa) Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids Inhibition of Speciociliatine for CYP2C19 In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- speciociliatine

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