Inhibition of CYP2C19 by Glycycoumarin CSV JSON


Natural product species Study name
Licorice (Glycyrrhiza inflata) Cytochrome P450 inhibition by licorice species Glycyrrhiza inflata and fourteen licorice constituents
Licorice (Glycyrrhiza uralensis) Cytochrome P450 inhibition by licorice species Glycyrrhiza uralensis and fourteen licorice constituents

In Vitro Enzyme Inhibition Experiment

Inhibition of CYP2C19 by Glycycoumarin

Inhibition was detected.  Cutoff used —

50 % inhibition

mephenytoin, (s)-

glycycoumarin

4-hydroxymephenytoin, (s)-

  • CYP2C19 4311137

Cell fraction Pooled human liver microsomes -7999662

Results

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

0.2 mg/mL

10 min

NADPH

50 µM

3.68 μg/mL