In Vitro Enzyme Inhibition Experiment

2C19 Inhibition by Hydrastine

Inhibition was detected.  Cutoff used — not specified

mephenytoin, (s)-


4-hydroxymephenytoin, (s)-

  • CYP2C19 4311137

Cell fraction Pooled human liver microsomes -7999662


Estimate from Fig 1 at 20 μM

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

In-house preparation

HHM-247 and HHM-258

15 min


10 min

No NADPH with precipitant

1 or 20 μM