Licorice (Glycyrrhiza uralensis)

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Latin Binomial: Glycyrrhiza uralensis
Common Names: Chinese licorice, Gan cao and Licorice

Natural Product Information From GSRS

Resource Identifier
= Induction
= Inhibition
= No overall effect

Published in vitro enzyme experiments

ethanolic extract of licorice g. uralensis
CYP2A6
CYP1A2
CYP2B6
CYP2C8
CYP2C9
CYP2C19
CYP2D6
CYP3A4
CYP2E1

Chemical characterization

liquiritin isoliquiritin licuraside liquiritigenin isoliquiritigenin glycyrrhizin glycyrrhetinic acid licoricidin p-hydroxy-benzylmalonic acid (hbma) glycycoumarin isoliquiritin apioside liquiritin apioside
Chemical characterization of Licorice, Glycyrrhiza uralensis 3.83 ± 0 % 0.33 ± 0 % 0.05 ± 0 % 0.23 ± 0 % 0.07 ± 0 % 4.2 ± 0 % 0.01 ± 0 % 0.08 ± 0 % 1.88 ± 0 % 0.13 ± 0 % 0.13 ± 0 % 1.09 ± 0 %
ID Subject of Study Study Name Name Type Overall Effect Enzymes Transporters Object Object Metabolite Precipitant
NPDI-ST3yYQ Licorice (Glycyrrhiza uralensis) Cytochrome P450 inhibition by licorice species Glycyrrhiza uralensis and fourteen licorice constituents Negligible inhibition of CYP2A6 by G. uralensis Licorice extract In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2A6
coumarin 7-hydroxycoumarin ethanolic extract of licorice g. uralensis
NPDI-DqqLBA Licorice (Glycyrrhiza uralensis) Cytochrome P450 inhibition by licorice species Glycyrrhiza uralensis and fourteen licorice constituents Negligible inhibition of CYP1A2 by G. uralensis Licorice extract In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP1A2
phenacetin acetaminophen ethanolic extract of licorice g. uralensis
NPDI-FQmbtQ Licorice (Glycyrrhiza uralensis) Cytochrome P450 inhibition by licorice species Glycyrrhiza uralensis and fourteen licorice constituents Inhibition of CYP2B6 by G. uralensis Licorice extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2B6
bupropion hydroxybupropion ethanolic extract of licorice g. uralensis
NPDI-955SOw Licorice (Glycyrrhiza uralensis) Cytochrome P450 inhibition by licorice species Glycyrrhiza uralensis and fourteen licorice constituents Inhibition of CYP2C8 by G. uralensis Licorice extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C8
amodiaquine n-desethylamodiaquine ethanolic extract of licorice g. uralensis
NPDI-SyZKkg Licorice (Glycyrrhiza uralensis) Cytochrome P450 inhibition by licorice species Glycyrrhiza uralensis and fourteen licorice constituents Inhibition of CYP2C9 by G. uralensis Licorice extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
tolbutamide hydroxymethyltolbutamide ethanolic extract of licorice g. uralensis
NPDI-c03hqA Licorice (Glycyrrhiza uralensis) Cytochrome P450 inhibition by licorice species Glycyrrhiza uralensis and fourteen licorice constituents Inhibition of CYP2C19 by G. uralensis Licorice extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- ethanolic extract of licorice g. uralensis
NPDI-kstb8w Licorice (Glycyrrhiza uralensis) Cytochrome P450 inhibition by licorice species Glycyrrhiza uralensis and fourteen licorice constituents Negligible Inhibition of CYP2D6 by G. uralensis Licorice extract In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2D6
dextromethorphan dextrorphan ethanolic extract of licorice g. uralensis
NPDI-aX49Ng Licorice (Glycyrrhiza uralensis) Cytochrome P450 inhibition by licorice species Glycyrrhiza uralensis and fourteen licorice constituents Negligible inhibition of CYP3A4 by G. uralensis Licorice extract In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP3A4
midazolam 1'-hydroxymidazolam ethanolic extract of licorice g. uralensis
NPDI--eqgUQ Licorice (Glycyrrhiza uralensis) Cytochrome P450 inhibition by licorice species Glycyrrhiza uralensis and fourteen licorice constituents Negligible inhibition of CYP3A4 by G. uralensis Licorice extract In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP3A4
testosterone 6beta-hydroxytestosterone ethanolic extract of licorice g. uralensis
NPDI-vgJV_w Licorice (Glycyrrhiza uralensis) Cytochrome P450 inhibition by licorice species Glycyrrhiza uralensis and fourteen licorice constituents Negligible inhibition of CYP2E1 by G. uralensis Licorice extract In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2E1
chloroxazone 6-hydroxychloroxazone ethanolic extract of licorice g. uralensis
NPDI-ebe-GA Licorice (Glycyrrhiza uralensis) Cytochrome P450 inhibition by licorice species Glycyrrhiza uralensis and fourteen licorice constituents Chemical characterization of Licorice, Glycyrrhiza uralensis Characterization of Material