- Natural product: Licorice (Glycyrrhiza uralensis)
- Associated study: Cytochrome P450 inhibition by licorice species Glycyrrhiza uralensis and fourteen licorice constituents
In Vitro Enzyme Inhibition Experiment
Inhibition of CYP2B6 by G. uralensis Licorice extract
Inhibition was detected. Cutoff used —
> 100 µg/mL
- CYP2B6 4308333
Cell fraction Pooled human liver microsomes -7999662
|Sample||Compound measured||Value||Measurement||Study sequence||Additional information||N replicates|
cocktail assay, IC50 values were determined according to the method of Li et al. (2015).
Li, G., Huang, K., Nikolic, D., van Breemen, R.B., 2015. High-throughput cytochrome P450 cocktail inhibition assay for assessing drug-drug and drug-botanical interactions. Drug Metab. Dispos. 43, 1670–1678.
11 concentrations from 0.005–250 μg/mL