Inhibition of CYP2C19 by G. uralensis Licorice extract CSV JSON

In Vitro Enzyme Inhibition Experiment

Inhibition of CYP2C19 by G. uralensis Licorice extract

Inhibition was detected.  Cutoff used —

> 100 µg/mL

mephenytoin, (s)-

4-hydroxymephenytoin, (s)-

  • CYP2C19 4311137

Cell fraction Pooled human liver microsomes -7999662

Results

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

0.2 mg/mL

10 min

NADPH

50 µM

11 concentrations from 0.005–250 μg/mL